The Caloosahatchee culture is an archaeological culture on the Gulf coast of Southwest Florida that lasted from about 500 to 1750 AD. Its territory consisted of the coast from Estero Bay to Charlotte Harbor and inland about halfway to Lake Okeechobee, approximately covering what are now Charlotte, Lee, and Collier counties. At the time of first European contact, the Caloosahatchee culture region formed the core of the Calusa domain.