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Variable number tandem repeat Répétition en tandem à nombre variable Número variable de repeticiones en tándem Variable Number of Tandem Repeat Variabel aantal tandemherhalingen 可变数目串联重复
rdfs:comment
A variable number tandem repeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length (number of repeats) among individuals. Each variant acts as an inherited allele, allowing them to be used for personal or parental identification. Their analysis is useful in genetics and biology research, forensics, and DNA fingerprinting. Een variabel aantal tandemherhalingen of VNTR (variable number tandem repeat) is een reeks van 10 tot 100 opeenvolgende genetische herhalingen van een genetische sequentie, die 14 tot 100 basenparen lang kan zijn. Termen die ook naar dergelijke herhalingen verwijzen zijn minisatelliet en microsatelliet, dit zijn specifieke vormen van VNTR's. Une répétition en tandem à nombre variable (ou VNTR pour variable number tandem repeat en anglais) correspond à un emplacement dans un génome où une courte séquence nucléotidique est organisée comme une répétition en tandem. On peut les trouver sur de nombreux chromosomes et elles montrent souvent des variations de longueur (nombre de répétitions) d'un individu à l'autre. Chaque variante agit comme un allèle hérité, ce qui permet de les utiliser pour une identification personnelle ou parentale. Leur analyse est utile dans la recherche génétique et biologique, la criminalistique et les empreintes digitales d'ADN. 可变数目串联重复（或VNTR）是基因组中的位置，其中被组织为串联重复。这些可以在许多染色体上找到，并且经常显示个体之间的长度变化（重复的数量）。 每个变体充当遗传等位基因，允许它们用于个人或父母。 他们的分析在遗传学和生物学研究，法医学和DNA指纹分析中很有用。 En genética molecular, el número variable de repeticiones en tándem o VNTR (acrónimo del inglés Variable Number of Tandem Repeats) son repeticiones de secuencias de 9 a 100 pares de bases que se utilizan como marcador molecular. El número de repeticiones es variable pero en general es menor a 1000. Estos se pueden encontrar en muchos cromosomas y, a menudo, muestran variaciones en la longitud (número de repeticiones) entre los individuos. Cada variante actúa como un alelo heredado, lo que permite su uso para la identificación personal o parental. Su análisis es útil en investigación genética y biológica, medicina forense y huellas genéticas In biologia molecolare, la sigla VNTR (dall'inglese Variable Number of Tandem Repeats, numero variabile di ripetizioni in tandem) viene utilizzata per indicare polimorfismi del DNA in cui la differenza tra le diverse varianti non è data da un cambio nucleotidico (come è invece per i SNP - polimorfismi a singolo nucleotide - o gli RFLP) ma dalla ripetizione in tandem di specifiche sequenze nucleotidiche. Le sequenze ripetute del nostro genoma sono diverse e di diversa origine e rappresentano circa il 44% del nostro DNA, quelle ripetute in tandem sono caratterizzate dal fatto che le unità di ripetizione si trovano adiacenti l'una all'altra mentre quelle che si definiscono intersperse possono anche trovarsi in punti distanti tra loro (ad esempio i retrotrasposoni).
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Een variabel aantal tandemherhalingen of VNTR (variable number tandem repeat) is een reeks van 10 tot 100 opeenvolgende genetische herhalingen van een genetische sequentie, die 14 tot 100 basenparen lang kan zijn. Termen die ook naar dergelijke herhalingen verwijzen zijn minisatelliet en microsatelliet, dit zijn specifieke vormen van VNTR's. Afhankelijk van welke repeats er plaatsvinden, kunnen ze aanleiding geven tot ziekten. Dit is dan een gevolg van mutaties tijdens een translatieproces. Een voorbeeld is een herhaling van de reeks cytosine–adenine–guanine, een zogenaamde CAG-repeat. Deze wordt gelinkt aan de ziekte van Huntington, prostaatkanker en de ziekte van Kennedy. VNTR's kunnen gebruikt worden voor onderzoek van populatiegenetica aan de hand van polymorfe loci: Zo is er een hexamorfe VNTR van 86 basenparen in intron 2 van de IL-1 receptorantagonist op chromosoom 2. Door de verschillende allelen uit te knippen met restrictie-enzymen en te visualiseren met gel-elektroforese, ontstaat een karakteristieke 'vingerafdruk'. 可变数目串联重复（或VNTR）是基因组中的位置，其中被组织为串联重复。这些可以在许多染色体上找到，并且经常显示个体之间的长度变化（重复的数量）。 每个变体充当遗传等位基因，允许它们用于个人或父母。 他们的分析在遗传学和生物学研究，法医学和DNA指纹分析中很有用。 Une répétition en tandem à nombre variable (ou VNTR pour variable number tandem repeat en anglais) correspond à un emplacement dans un génome où une courte séquence nucléotidique est organisée comme une répétition en tandem. On peut les trouver sur de nombreux chromosomes et elles montrent souvent des variations de longueur (nombre de répétitions) d'un individu à l'autre. Chaque variante agit comme un allèle hérité, ce qui permet de les utiliser pour une identification personnelle ou parentale. Leur analyse est utile dans la recherche génétique et biologique, la criminalistique et les empreintes digitales d'ADN. In biologia molecolare, la sigla VNTR (dall'inglese Variable Number of Tandem Repeats, numero variabile di ripetizioni in tandem) viene utilizzata per indicare polimorfismi del DNA in cui la differenza tra le diverse varianti non è data da un cambio nucleotidico (come è invece per i SNP - polimorfismi a singolo nucleotide - o gli RFLP) ma dalla ripetizione in tandem di specifiche sequenze nucleotidiche. Le sequenze ripetute del nostro genoma sono diverse e di diversa origine e rappresentano circa il 44% del nostro DNA, quelle ripetute in tandem sono caratterizzate dal fatto che le unità di ripetizione si trovano adiacenti l'una all'altra mentre quelle che si definiscono intersperse possono anche trovarsi in punti distanti tra loro (ad esempio i retrotrasposoni). A variable number tandem repeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length (number of repeats) among individuals. Each variant acts as an inherited allele, allowing them to be used for personal or parental identification. Their analysis is useful in genetics and biology research, forensics, and DNA fingerprinting. En genética molecular, el número variable de repeticiones en tándem o VNTR (acrónimo del inglés Variable Number of Tandem Repeats) son repeticiones de secuencias de 9 a 100 pares de bases que se utilizan como marcador molecular. El número de repeticiones es variable pero en general es menor a 1000. Estos se pueden encontrar en muchos cromosomas y, a menudo, muestran variaciones en la longitud (número de repeticiones) entre los individuos. Cada variante actúa como un alelo heredado, lo que permite su uso para la identificación personal o parental. Su análisis es útil en investigación genética y biológica, medicina forense y huellas genéticas
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