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Statements

Subject Item
dbr:Dehydronorketamine
rdf:type
dbo:ChemicalCompound owl:Thing dbo:Drug wikidata:Q8386 n19:ChemicalObject dbo:ChemicalSubstance
rdfs:label
Dehydronorketamine
rdfs:comment
Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DH
foaf:depiction
n15:5,6-Dehydronorketamine.svg
dcterms:subject
dbc:Cyclohexenes dbc:Amines dbc:Enones dbc:Human_drug_metabolites dbc:Nicotinic_antagonists dbc:Chloroarenes
dbo:wikiPageID
46936167
dbo:wikiPageRevisionID
1057373142
dbo:wikiPageWikiLink
dbr:Hydroxynorketamine dbr:Esketamine dbr:Ketamine dbr:NMDA_receptor dbr:Norketamine dbr:Forced_swim_test dbr:Drug_test dbc:Cyclohexenes dbr:Antidepressant dbr:Negative_allosteric_modulator dbr:Arketamine dbc:Amines dbc:Enones dbc:Human_drug_metabolites dbr:Alpha-3_beta-4_nicotinic_receptor dbr:Dehydrogenation dbr:IC50 dbc:Nicotinic_antagonists dbr:Alpha-7_nicotinic_receptor dbr:Metabolite dbc:Chloroarenes
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dbo:thumbnail
n15:5,6-Dehydronorketamine.svg?width=300
dbp:atcPrefix
None
dbp:c
12
dbp:casNumber
57683
dbp:chemspiderid
142954
dbp:cl
1
dbp:h
12
dbp:iupacName
6
dbp:n
1
dbp:o
1
dbp:pubchem
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dbp:smiles
C1CCN
dbp:stdinchi
1
dbp:stdinchikey
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dbp:unii
J5442FVV58
dbo:abstract
Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DHNK). It can be detected 7–10 days after a modest dose of ketamine, and because of this, is useful in drug detection assays.
gold:hypernym
dbr:Metabolite
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5649
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J5442FVV58
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wikipedia-en:Dehydronorketamine
Subject Item
dbr:Hydroxynorketamine
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dbr:Dehydronorketamine
Subject Item
dbr:C12H12ClNO
dbo:wikiPageWikiLink
dbr:Dehydronorketamine
dbo:wikiPageRedirects
dbr:Dehydronorketamine
Subject Item
dbr:Alpha-7_nicotinic_receptor
dbo:wikiPageWikiLink
dbr:Dehydronorketamine
Subject Item
dbr:Norketamine
dbo:wikiPageWikiLink
dbr:Dehydronorketamine
Subject Item
dbr:Ketamine
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dbr:Dehydronorketamine
Subject Item
dbr:DHNK
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dbr:Dehydronorketamine
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dbr:Dehydronorketamine
Subject Item
dbr:5,6-Dehydronorketamine
dbo:wikiPageWikiLink
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dbr:Dehydronorketamine
Subject Item
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