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- Hydroxynorketamin (HNK) ist ein Metabolit von Ketamin, welches durch Hydroxylierung seines Metaboliten Norketamin gebildet wird. Im Gegensatz zu Ketamin und Norketamin ist Hydroxynorketamin als Anästhetikum und Dissoziativum inaktiv und produziert keine Rauschzustände. (de)
- Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine. As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression. The major metabolite of ketamine is norketamine (80%). Norketamine is secondarily converted into 4-, 5-, and 6-hydroxynorketamines (15%), mainly HNK (6-hydroxynorketamine). Ketamine is also transformed into hydroxyketamine (5%). As such, bioactivated HNK comprises less than 15% of a dose of ketamine. (en)
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- 16840 (xsd:nonNegativeInteger)
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- The four possible stereoisomers of Hydroxynorketamine (en)
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- -Hydroxynorketamine Formula V1.svg (en)
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- -Hydroxynorketamine Formula V1.svg (en)
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- -Hydroxynorketamine Formula V1.svg (en)
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- CFBVGSWSOJBYGC-UHFFFAOYSA-N (en)
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- HNK; 6-Hydroxynorketamine; 6-HNK (en)
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- Hydroxynorketamin (HNK) ist ein Metabolit von Ketamin, welches durch Hydroxylierung seines Metaboliten Norketamin gebildet wird. Im Gegensatz zu Ketamin und Norketamin ist Hydroxynorketamin als Anästhetikum und Dissoziativum inaktiv und produziert keine Rauschzustände. (de)
- Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine. As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression. (en)
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- Hydroxynorketamin (de)
- Hydroxynorketamine (en)
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