About: Vorozole

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org:8891

Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

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dbo:abstract
  • Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane. (en)
dbo:casNumber
  • 129731-10-8
dbo:chEMBL
  • 224060
dbo:fdaUniiCode
  • 1E2S9YXV2A
dbo:kegg
  • D03786
dbo:pubchem
  • 6918191
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  • L02 (en)
dbp:atcSuffix
  • BG05 (en)
dbp:bioavailability
  • Very high (en)
dbp:c
  • 16 (xsd:integer)
dbp:casNumber
  • 129731 (xsd:integer)
dbp:chembl
  • 224060 (xsd:integer)
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  • 1 (xsd:integer)
dbp:eliminationHalfLife
  • 28800.0
dbp:h
  • 13 (xsd:integer)
dbp:iupacName
  • 6 (xsd:integer)
dbp:kegg
  • D03786 (en)
dbp:metabolism
  • Hepatic (en)
dbp:n
  • 6 (xsd:integer)
dbp:pubchem
  • 6918191 (xsd:integer)
dbp:smiles
  • Clc1ccc[C@@H]n4ncnc4 (en)
dbp:synonyms
  • R-76713; Rizivor (en)
dbp:unii
  • 100 (xsd:integer)
dbp:verifiedfields
  • changed (en)
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dbp:watchedfields
  • changed (en)
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  • Vorozole (developmental code name R-76713; former tentative brand name Rizivor) is a triazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane. (en)
rdfs:label
  • Vorozole (en)
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