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- La trypannothion disulfure réductase est une oxydoréductase qui catalyse la réaction : trypanothion + NADP+ disulfure de trypanothion + NADPH + H+. Cette enzyme est spécifique aux kinétoplastidés, protozoaires parasitiques tels que Leishmania et Trypanosoma, chez lesquels elle permet de régénérer le trypanothion à partir du disulfure de trypanothion et de NADPH. (fr)
- In enzymology, a trypanothione-disulfide reductase (EC 1.8.1.12) is an enzyme that catalyzes the chemical reaction trypanothione + NADP+ trypanothione disulfide + NADPH + H+ Thus, the two substrates of this enzyme are trypanothione and NADP+, whereas its 3 products are , NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trypanothione:NADP+ oxidoreductase. Other names in common use include trypanothione reductase, and NADPH2:trypanothione oxidoreductase. It employs one cofactor, FAD. The X-ray crystal structures of trypanothione reductase enzymes from several trypanosomatids species have been solved, including those from Crithidia fasciculata, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The structures reveal that trypanothione reductase forms homodimers in solution with each of the two individual subunits comprising an FAD-binding domain, an NADPH-binding domain and an interface domain. Examples of trypanothione reducatse inhibitors include 5-Nitro-Imidazole, Febrifugine, Imipramine and Benzoxaborole. (en)
- トリパノチオンジスルフィドレダクターゼ（trypanothione-disulfide reductase）は、次の化学反応を触媒する酸化還元酵素である。 トリパノチオン + NADP+ トリパノチオンジスルフィド + NADPH + H+ 反応式の通り、この酵素の基質はとH2OとNADP+、生成物はとNADPHとH+である。補因子としてFADを用いる。 組織名はtrypanothione:NADP+ oxidoreductaseで、別名にtrypanothione reductase、NADPH2:trypanothione oxidoreductaseがある。 (ja)
- La tripanotione-disolfuro reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: + NADP+ ⇄ tripanotione disolfuro + NADPH + H+ Il tripanotione disolfuro è la forma ossidata della N1,N8-bis(glutationil)-spermidina presente in , un parassita degli insetti. L'enzima di tale specie è una flavoproteina la cui attività è dipendente dallo stato redox di una cistina presente nel sito attivo. (it)
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- 6177 (xsd:nonNegativeInteger)
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- trypanothione-disulfide reductase (en)
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- La trypannothion disulfure réductase est une oxydoréductase qui catalyse la réaction : trypanothion + NADP+ disulfure de trypanothion + NADPH + H+. Cette enzyme est spécifique aux kinétoplastidés, protozoaires parasitiques tels que Leishmania et Trypanosoma, chez lesquels elle permet de régénérer le trypanothion à partir du disulfure de trypanothion et de NADPH. (fr)
- トリパノチオンジスルフィドレダクターゼ（trypanothione-disulfide reductase）は、次の化学反応を触媒する酸化還元酵素である。 トリパノチオン + NADP+ トリパノチオンジスルフィド + NADPH + H+ 反応式の通り、この酵素の基質はとH2OとNADP+、生成物はとNADPHとH+である。補因子としてFADを用いる。 組織名はtrypanothione:NADP+ oxidoreductaseで、別名にtrypanothione reductase、NADPH2:trypanothione oxidoreductaseがある。 (ja)
- La tripanotione-disolfuro reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: + NADP+ ⇄ tripanotione disolfuro + NADPH + H+ Il tripanotione disolfuro è la forma ossidata della N1,N8-bis(glutationil)-spermidina presente in , un parassita degli insetti. L'enzima di tale specie è una flavoproteina la cui attività è dipendente dallo stato redox di una cistina presente nel sito attivo. (it)
- In enzymology, a trypanothione-disulfide reductase (EC 1.8.1.12) is an enzyme that catalyzes the chemical reaction trypanothione + NADP+ trypanothione disulfide + NADPH + H+ Thus, the two substrates of this enzyme are trypanothione and NADP+, whereas its 3 products are , NADPH, and H+. (en)
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- Trypanothion disulfure réductase (fr)
- Tripanotione-disolfuro reduttasi (it)
- トリパノチオンジスルフィドレダクターゼ (ja)
- Trypanothione-disulfide reductase (en)
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- trypanothione-disulfide reductase (en)
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