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- Das Trans-activation response element ist ein Teil des genetischen Codes von HI-Viren. Das TAR-Element hat zwei Funktionen.Zum einen dient es als Erkennungs-Region für das virale Tat-Protein, das die Übersetzung der Virusbausteine reguliert. Zum anderen dient es als Vorläufer von Mikro-RNA, die Einfluss auf die Regulation der Wirtsproteine nimmt. Vor allen Dingen wird die Apoptose der befallenen Zellen gehemmt. (de)
- The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter. Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim. Human polyomavirus 2 (JC virus) contains a TAR-homologous sequence in its late promoter that is responsive to HIV-1 derived Tat. (en)
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- 5506 (xsd:nonNegativeInteger)
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- Predicted secondary structure and sequence conservation of mir-TAR (en)
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- Trans-activation response element (en)
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- Das Trans-activation response element ist ein Teil des genetischen Codes von HI-Viren. Das TAR-Element hat zwei Funktionen.Zum einen dient es als Erkennungs-Region für das virale Tat-Protein, das die Übersetzung der Virusbausteine reguliert. Zum anderen dient es als Vorläufer von Mikro-RNA, die Einfluss auf die Regulation der Wirtsproteine nimmt. Vor allen Dingen wird die Apoptose der befallenen Zellen gehemmt. (de)
- The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter. Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim. (en)
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- Trans-activation Response Element (de)
- Trans-activation response element (TAR) (en)
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