Merle Catherine Chambers (born 1946) is an American lawyer, business executive, and philanthropist. She founded and served as CEO of Axem Resources, a private oil and gas exploration and production company, from 1980 to 1997, and since 1997 is the president and CEO of Leith Ventures, a private investment firm. She chairs the Merle Chambers Fund (formerly Chambers Family Fund), which supports equity, democracy and women's economic security. She is also an active political contributor in Colorado, focusing on Democratic and women candidates. The recipient of numerous awards and honors, she was inducted into the Colorado Women's Hall of Fame in 2004, the Rocky Mountain Oil & Gas Hall of Fame in 2009, and the Colorado Business Hall of Fame in 2010.