Mazaediothecium uniseptatum is a species of calicioid lichen in the family Pyrenulaceae. Found in French Guiana, it was formally described as a new species in 2015 by Dutch lichenologist André Aptroot. The type specimen was collected near the village sentier Limonade in Saül at an altitude of 300 m (980 ft); here, in a mixed forest, the lichen was found growing on the higher trunk of a Protium tree. It has a dull, greyish-white thallus that lacks a cortex and is surrounded by a brown prothallus line. The apothecia are black but covered in their upper half with a golden yellow pruina; they are about 0.2 mm in diameter and up to 0.6 mm high. The asci soon disintegrate to form a mazaedium layer. Ascospores are pale grey with a shape ranging from ellipsoid to spindle-shaped (fusiform), and mea
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