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- MC3T3 is an osteoblast precursor cell line derived from Mus musculus (mouse) calvaria. A number of derivatives of this strain have been isolated to select for varying degrees of osteogenic potential, and have been widely used as model systems in bone biology. A standard textbook calls its MC3T3-E1 sub-line "one of the most convenient and physiologically relevant systems for study of transcriptional control in calvarial osteoblasts." This is a spontaneously transformed ( immortalized ) cell line. As such, it is a very convenient research tool but caution should be used when extrapolating these results to normal cells, and even more, to normal human cells. The MC3T3 cell line is also used for modeling skeletal tissue regeneration because its undifferentiated state is phenotypically similar to that of an osteochondroprogenitor cell. One published research article, using MC3T3-E1 cells as a model for studying cartilage regeneration, describes some of the specific limitations of the cell line for understanding behavior in human cells. (en)
- MC3T3是源自小鼠顱頂的成骨細胞前體細胞系。目前已經分離出MC3T3細胞的許多衍生物，以選擇不同程度的成骨潛力，並且已被廣泛用作研究骨生物學的模型系統。有教科書將其子系細胞，稱為研究着顱骨成骨細胞轉錄控制的最方便系統之一。這是一種自發轉化的及永生化的細胞系，故而是非常方便的研究工具，但是在將這些結論外推到正常細胞或正常人類細胞時，應該要謹慎判斷 。 (zh)
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- MC3T3是源自小鼠顱頂的成骨細胞前體細胞系。目前已經分離出MC3T3細胞的許多衍生物，以選擇不同程度的成骨潛力，並且已被廣泛用作研究骨生物學的模型系統。有教科書將其子系細胞，稱為研究着顱骨成骨細胞轉錄控制的最方便系統之一。這是一種自發轉化的及永生化的細胞系，故而是非常方便的研究工具，但是在將這些結論外推到正常細胞或正常人類細胞時，應該要謹慎判斷 。 (zh)
- MC3T3 is an osteoblast precursor cell line derived from Mus musculus (mouse) calvaria. A number of derivatives of this strain have been isolated to select for varying degrees of osteogenic potential, and have been widely used as model systems in bone biology. A standard textbook calls its MC3T3-E1 sub-line "one of the most convenient and physiologically relevant systems for study of transcriptional control in calvarial osteoblasts." This is a spontaneously transformed ( immortalized ) cell line. As such, it is a very convenient research tool but caution should be used when extrapolating these results to normal cells, and even more, to normal human cells. (en)
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