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Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. It is a type of glomerulonephritis in which the glomeruli become inflamed. Since it is a result of SLE, this type of glomerulonephritis is said to be secondary, and has a different pattern and outcome from conditions with a primary cause originating in the kidney. The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney biopsy. On urinalysis, a nephritic picture is found and red blood cell casts, red blood cells and proteinuria is found.

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dbo:abstract
  • ذئبة التهاب الكلى أو التهاب الكلية الذئبي(Lupus nephritis) هو التهاب في الكلية بسبب الذئبة الحُمامية المجموعية (Systemic lupus erythematosus, SLE)، وهو مرض في الجهاز المناعيّ. على خلاف ضرر الكلية، من الممكن أن يسبب هذا المرض ضرراً للجلد والمفاصل والجهاز العصبي، وبدرجة أقل، أي عضو أو جهاز آخر في الجسم. (ar)
  • Le lupus est une maladie auto-immune systémique qui peut toucher plusieurs organes. L’atteinte rénale (aussiappelée « glomérulonéphrite lupique » car touchant le « glomérule » qui est la structure interne du rein) est uneinflammation du rein causée par le lupus. Cette complication - qui survient chez près de la moitié (40 %) des patientsatteints de lupus systémique [1, 2] - peut être présente dès le début de la maladie ou apparaitre secondairementpendant le suivi.Cette atteinte rénale comporte plusieurs stades (il existe 6 classes de glomérulonéphrites lupiques selon laclassification ISN/RPS 2003 [2-4] ), et la phase terminale - qui touche 4-10% des patients avec une atteinte rénale [2,5] - reste une préoccupation pour tous les patients lupiques en raison de sa sévérité (handicap, décès). Cependant,les études montrent qu’une prise en charge rapide et adaptée réduit considérablement le risque de dommagesirréversibles [2, 6-11] . (fr)
  • Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. It is a type of glomerulonephritis in which the glomeruli become inflamed. Since it is a result of SLE, this type of glomerulonephritis is said to be secondary, and has a different pattern and outcome from conditions with a primary cause originating in the kidney. The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney biopsy. On urinalysis, a nephritic picture is found and red blood cell casts, red blood cells and proteinuria is found. (en)
  • La nefrite lupica è un'entità clinico-patologica caratterizzata da un'alterazione della struttura e della funzione renale in corso di lupus eritematoso sistemico. (it)
  • SLE-nefrit drabbar mer än 50 procent av barn med SLE (systemisk lupus erythematosus). Förekomsten av glomerulonefrit är en av de viktigast prognostiska faktorerna i långtidsprognosen för dessa barn. Alla barn med SLE som har blod eller protein i urinen bör göra en njurbiopsi. Sjukdomen behandlas primärt med kortison. Immunhämmande medel kan bli aktuella som behandling. (sv)
  • Nefropatia toczniowa – glomerulopatia wtórna zapalna, w której uszkodzenie miąższu nerek spowodowane jest toczniem rumieniowatym układowym. Do zmian w nerkach dochodzi u około 50% chorych z SLE. Objawia się białkomoczem, krwiomoczem, nadciśnieniem tętniczym, niewydolnością nerek. Klasyfikacja histopatologiczna WHO (1982, rewizja w 1995): * Klasa I: minimalne zmiany mezangialne (ang. minimal mesangial glomerulonephritis; 10-25%) * Klasa II: zmiany mezangialne rozplemowe ze złogami w mezangium (ang. mesangial proliferative glomerulonephritis) * Klasa III: ogniskowe rozplemowe kłębuszkowe zapalenie nerek (ang. focal proliferative nephritis; 20-35%) * Klasa IV: rozlane rozplemowe lub błoniastorozplemowe kłębuszkowe zapalenie nerek (ang. diffuse proliferative nephritis; 35-60%) * Klasa V: błoniaste kłębuszkowe zapalenie nerek (ang. membranous nephritis) * Klasa VI: zaawansowane stwardnienie kłębuszków (ang. glomerulosclerosis) (pl)
  • Nefrite lúpica é uma inflamação do rim causada por lúpus eritematoso sistêmico (LES), uma doença do sistema imune. Além dos rins, o LES pode causar lesões em pele, articulações, sistema nervoso e virtualmente qualquer órgão ou sistema no corpo. (pt)
  • 狼瘡腎炎(Lupus nephritis)是紅斑性狼瘡(SLE)造成的腎臟炎症,屬於一種免疫系统的疾病。除了腎臟,SLE也會損害皮膚、關節、神經系統和在體內的幾乎任何器官或系統。 (zh)
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dbp:caption
  • Micrograph of diffuse proliferative lupus nephritis showing increased mesangial matrix and mesangial hypercellularity. Kidney biopsy. PAS stain. (en)
dbp:causes
  • Complication of systemic lupus erythematosus. (en)
dbp:diagnosis
  • Complement levels, Urinalysis (en)
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  • Lupus nephritis (en)
dbp:symptoms
  • Joint pain or swelling (en)
dbp:synonyms
  • SLE nephritis (en)
dbp:treatment
  • Corticosteroids may be used (en)
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  • ذئبة التهاب الكلى أو التهاب الكلية الذئبي(Lupus nephritis) هو التهاب في الكلية بسبب الذئبة الحُمامية المجموعية (Systemic lupus erythematosus, SLE)، وهو مرض في الجهاز المناعيّ. على خلاف ضرر الكلية، من الممكن أن يسبب هذا المرض ضرراً للجلد والمفاصل والجهاز العصبي، وبدرجة أقل، أي عضو أو جهاز آخر في الجسم. (ar)
  • Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. It is a type of glomerulonephritis in which the glomeruli become inflamed. Since it is a result of SLE, this type of glomerulonephritis is said to be secondary, and has a different pattern and outcome from conditions with a primary cause originating in the kidney. The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney biopsy. On urinalysis, a nephritic picture is found and red blood cell casts, red blood cells and proteinuria is found. (en)
  • La nefrite lupica è un'entità clinico-patologica caratterizzata da un'alterazione della struttura e della funzione renale in corso di lupus eritematoso sistemico. (it)
  • SLE-nefrit drabbar mer än 50 procent av barn med SLE (systemisk lupus erythematosus). Förekomsten av glomerulonefrit är en av de viktigast prognostiska faktorerna i långtidsprognosen för dessa barn. Alla barn med SLE som har blod eller protein i urinen bör göra en njurbiopsi. Sjukdomen behandlas primärt med kortison. Immunhämmande medel kan bli aktuella som behandling. (sv)
  • Nefrite lúpica é uma inflamação do rim causada por lúpus eritematoso sistêmico (LES), uma doença do sistema imune. Além dos rins, o LES pode causar lesões em pele, articulações, sistema nervoso e virtualmente qualquer órgão ou sistema no corpo. (pt)
  • 狼瘡腎炎(Lupus nephritis)是紅斑性狼瘡(SLE)造成的腎臟炎症,屬於一種免疫系统的疾病。除了腎臟,SLE也會損害皮膚、關節、神經系統和在體內的幾乎任何器官或系統。 (zh)
  • Le lupus est une maladie auto-immune systémique qui peut toucher plusieurs organes. L’atteinte rénale (aussiappelée « glomérulonéphrite lupique » car touchant le « glomérule » qui est la structure interne du rein) est uneinflammation du rein causée par le lupus. Cette complication - qui survient chez près de la moitié (40 %) des patientsatteints de lupus systémique [1, 2] - peut être présente dès le début de la maladie ou apparaitre secondairementpendant le suivi.Cette atteinte rénale comporte plusieurs stades (il existe 6 classes de glomérulonéphrites lupiques selon laclassification ISN/RPS 2003 [2-4] ), et la phase terminale - qui touche 4-10% des patients avec une atteinte rénale [2,5] - reste une préoccupation pour tous les patients lupiques en raison de sa sévérité (handicap, décès). (fr)
  • Nefropatia toczniowa – glomerulopatia wtórna zapalna, w której uszkodzenie miąższu nerek spowodowane jest toczniem rumieniowatym układowym. Do zmian w nerkach dochodzi u około 50% chorych z SLE. Objawia się białkomoczem, krwiomoczem, nadciśnieniem tętniczym, niewydolnością nerek. Klasyfikacja histopatologiczna WHO (1982, rewizja w 1995): (pl)
rdfs:label
  • ذئبة التهاب الكلى (ar)
  • Glomérulonéphrite lupique (fr)
  • Nefrite lupica (it)
  • Lupus nephritis (en)
  • Nefropatia toczniowa (pl)
  • Nefrite lúpica (pt)
  • SLE-nefrit (sv)
  • 狼瘡性腎炎 (zh)
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