| dbo:abstract
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- LINE1 (also L1 and LINE-1) is a family of related class I transposable elements in the DNA of some organisms, classified with the long interspersed nuclear elements (LINEs). L1 transposons comprise approximately 17% of the human genome. The majority of these are inactive, though about 80–100 have retained the ability to retrotranspose, with considerable variation between individuals. These active L1s can interrupt the genome through insertions, deletions, rearrangements, and copy number variations. L1 activity has contributed to the instability and evolution of genomes and is tightly regulated in the germline by DNA methylation, histone modifications, and piRNA. L1s can further impact genome variation through mispairing and unequal crossing over during meiosis due to its repetitive DNA sequences. L1 gene products are also required by many non-autonomous Alu and SVA SINE retrotransposons. Mutations induced by L1 and its non-autonomous counterparts have been found to cause a variety of heritable and somatic diseases. In 2011, human L1 was reportedly discovered in the genome of the gonorrhea bacteria, evidently having arrived there by horizontal gene transfer. (en)
- LINE1（也称作L1或LINE-1）是DNA转座子长散在核元件（Long interspersed nuclear elements，LINEs）的一种，L1约占人類基因組的17%。 在人类基因组中，大部分的L1都是失活的，但仍保持着反转录转座的能力。 (zh)
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- 26191 (xsd:nonNegativeInteger)
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| dbp:altsymbols
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- L1ORF1p (en)
- L1ORF2p (en)
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| dbp:arm
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| dbp:band
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| dbp:chromosome
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- 1 (xsd:integer)
- 22 (xsd:integer)
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| dbp:entrezgene
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- 4029 (xsd:integer)
- 4030 (xsd:integer)
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| dbp:hgncid
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- 6686 (xsd:integer)
- 6687 (xsd:integer)
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| dbp:name
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- LINE-1 retrotransposable element ORF1 (en)
- LINE-1 retrotransposable element ORF2 (en)
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| dbp:pdb
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- 1 (xsd:integer)
- 2 (xsd:integer)
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- Q18028646 (en)
- Q18028649 (en)
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| rdfs:comment
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- LINE1（也称作L1或LINE-1）是DNA转座子长散在核元件（Long interspersed nuclear elements，LINEs）的一种，L1约占人類基因組的17%。 在人类基因组中，大部分的L1都是失活的，但仍保持着反转录转座的能力。 (zh)
- LINE1 (also L1 and LINE-1) is a family of related class I transposable elements in the DNA of some organisms, classified with the long interspersed nuclear elements (LINEs). L1 transposons comprise approximately 17% of the human genome. The majority of these are inactive, though about 80–100 have retained the ability to retrotranspose, with considerable variation between individuals. These active L1s can interrupt the genome through insertions, deletions, rearrangements, and copy number variations. L1 activity has contributed to the instability and evolution of genomes and is tightly regulated in the germline by DNA methylation, histone modifications, and piRNA. L1s can further impact genome variation through mispairing and unequal crossing over during meiosis due to its repetitive DNA seq (en)
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