About: John W. Semple

An Entity of Type: person, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org:8891

John W. Semple is a Canadian Scientist at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenic purpura (ITP). ITP is the condition of having a low platelet count (thrombocytopenia) and most causes appear to be related to antibodies against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was sh

Property Value
dbo:abstract
  • John W. Semple is a Canadian Scientist at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenic purpura (ITP). ITP is the condition of having a low platelet count (thrombocytopenia) and most causes appear to be related to antibodies against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was shown by others to be responsible for many of the autoimmune mechanisms causing the disorder.).The importance of understanding the T cell defects in ITP is that novel therapies aimed at these cells may significantly benefit patients with ITP. (en)
dbo:wikiPageExternalLink
dbo:wikiPageID
  • 10983360 (xsd:integer)
dbo:wikiPageLength
  • 4529 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1041969350 (xsd:integer)
dbo:wikiPageWikiLink
dbp:bot
  • InternetArchiveBot (en)
dbp:date
  • February 2020 (en)
dbp:fixAttempted
  • yes (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • John W. Semple is a Canadian Scientist at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenic purpura (ITP). ITP is the condition of having a low platelet count (thrombocytopenia) and most causes appear to be related to antibodies against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was sh (en)
rdfs:label
  • John W. Semple (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageDisambiguates of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License