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The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells. EBNA2 acts as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins, JK recombination signal-binding protein (RBP-JK), and PU.1 as well as working with multiple members of the RNA polymerase II transcription complex.

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  • The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells. EBNA2 acts as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins, JK recombination signal-binding protein (RBP-JK), and PU.1 as well as working with multiple members of the RNA polymerase II transcription complex. (en)
  • EBV antígeno nuclear 2 es una proteína viral asociada con el virus de Epstein-Barr.​ EBNA-2 es la principal transactivador viral, el cambio de la transcripción de los promotores Wp inicialmente utilizados después de la infección con el promotor Cp. Junto con EBNA-3C, sino que también activa el promotor de LMP-1. Se sabe que se unen el anfitrión de la proteína RBP-Jκ que juega un papel clave en la ruta de señalización Notch. EBNA-2 es esencial para la transformación del crecimiento mediada por VEB. (es)
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  • Epstein-Barr virus (en)
dbp:symbol
  • EBNA2 (en)
dbp:uniprot
  • P12978 (en)
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  • The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells. EBNA2 acts as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins, JK recombination signal-binding protein (RBP-JK), and PU.1 as well as working with multiple members of the RNA polymerase II transcription complex. (en)
  • EBV antígeno nuclear 2 es una proteína viral asociada con el virus de Epstein-Barr.​ EBNA-2 es la principal transactivador viral, el cambio de la transcripción de los promotores Wp inicialmente utilizados después de la infección con el promotor Cp. Junto con EBNA-3C, sino que también activa el promotor de LMP-1. Se sabe que se unen el anfitrión de la proteína RBP-Jκ que juega un papel clave en la ruta de señalización Notch. EBNA-2 es esencial para la transformación del crecimiento mediada por VEB. (es)
rdfs:label
  • EBV antígeno nuclear 2 (es)
  • Epstein–Barr virus nuclear antigen 2 (en)
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