About: Epstein–Barr virus nuclear antigen 1

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Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). It is the only EBV protein found in all EBV-related malignancies. It is important in establishing and maintaining the altered state that cells take when infected with EBV. EBNA1 has a glycine–alanine repeat sequence that separates the protein into amino- and carboxy-terminal domains. This sequence also seems to stabilize the protein, preventing proteasomal breakdown, as well as impairing antigen processing and MHC class I-restricted antigen presentation. This thereby inhibits the CD8-restricted cytotoxic T cell response against virus-infected cells. EBNA1 is expressed from the Qp promoter during all latency programs. It is the only viral protein expressed in latency

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dbo:abstract
  • Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). It is the only EBV protein found in all EBV-related malignancies. It is important in establishing and maintaining the altered state that cells take when infected with EBV. EBNA1 has a glycine–alanine repeat sequence that separates the protein into amino- and carboxy-terminal domains. This sequence also seems to stabilize the protein, preventing proteasomal breakdown, as well as impairing antigen processing and MHC class I-restricted antigen presentation. This thereby inhibits the CD8-restricted cytotoxic T cell response against virus-infected cells. EBNA1 is expressed from the Qp promoter during all latency programs. It is the only viral protein expressed in latency program I. (en)
dbo:symbol
  • EBV-NA1
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  • 21373569 (xsd:integer)
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  • 8590 (xsd:nonNegativeInteger)
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  • 1041058681 (xsd:integer)
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dbp:interpro
  • IPR004186 (en)
dbp:name
  • Epstein Barr virus nuclear antigen-1, DNA-binding domain (en)
dbp:pfam
  • PF02905 (en)
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  • 1 (xsd:integer)
dbp:symbol
  • EBV-NA1 (en)
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rdfs:comment
  • Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). It is the only EBV protein found in all EBV-related malignancies. It is important in establishing and maintaining the altered state that cells take when infected with EBV. EBNA1 has a glycine–alanine repeat sequence that separates the protein into amino- and carboxy-terminal domains. This sequence also seems to stabilize the protein, preventing proteasomal breakdown, as well as impairing antigen processing and MHC class I-restricted antigen presentation. This thereby inhibits the CD8-restricted cytotoxic T cell response against virus-infected cells. EBNA1 is expressed from the Qp promoter during all latency programs. It is the only viral protein expressed in latency (en)
rdfs:label
  • Epstein–Barr virus nuclear antigen 1 (en)
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