About: Epostane

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org:8891

Epostane (INN, USAN, BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as a contraceptive, abortifacient, and oxytocic drug but was never marketed. By inhibiting 3β-HSD, epostane blocks the biosynthesis of progesterone from pregnenolone (and also the conversion of dehydroepiandrosterone to androstenedione), thereby functioning as an antiprogestogen and terminating pregnancy. The drug was trialed and in a study was found to be slightly more effective at inducing abortion relative to mifepristone.

Property	Value
dbo:abstract	Epostane (INN, USAN, BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as a contraceptive, abortifacient, and oxytocic drug but was never marketed. By inhibiting 3β-HSD, epostane blocks the biosynthesis of progesterone from pregnenolone (and also the conversion of dehydroepiandrosterone to androstenedione), thereby functioning as an antiprogestogen and terminating pregnancy. The drug was trialed and in a study was found to be slightly more effective at inducing abortion relative to mifepristone. (en)
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dbo:chEMBL	2106218
dbo:fdaUniiCode	6375T36951
dbo:pubchem	6917713
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dbp:pubchem	6917713 (xsd:integer)
dbp:smiles	C[C@]12CC[C@H]3[C@H]CC[C@]45[C@@]3C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	CETKWEWBSMKADK-GSXVSZIWSA-N (en)
dbp:synonyms	WIN-32729 (en)
dbp:unii	6375 (xsd:integer)
dbp:width	250 (xsd:integer)
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dcterms:subject	dbc:Androstanes dbc:Cyclohexenols dbc:Enols dbc:Epoxides dbc:Sterols dbc:1-Methylcyclopentanols dbc:Antiprogestogens dbc:Nitriles dbc:3β-Hydroxysteroid_dehydrogenase_inhibitors
gold:hypernym	dbr:Inhibitor
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rdfs:comment	Epostane (INN, USAN, BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as a contraceptive, abortifacient, and oxytocic drug but was never marketed. By inhibiting 3β-HSD, epostane blocks the biosynthesis of progesterone from pregnenolone (and also the conversion of dehydroepiandrosterone to androstenedione), thereby functioning as an antiprogestogen and terminating pregnancy. The drug was trialed and in a study was found to be slightly more effective at inducing abortion relative to mifepristone. (en)
rdfs:label	Epostane (en)
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is foaf:primaryTopic of	wikipedia-en:Epostane