About: ERB-79

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org:8891

ERB-79 is a synthetic estrogen and a selective agonist of the ERβ. It is a racemic mixture, with the active enantiomer being ERB-26. ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα. Its EC50 value for the ERβ is 0.448 nM (14.52% of the potency of estradiol) and for the ERα is 79 nM (0.03% of the potency of estradiol). It has no antagonistic activity at either receptor. ERB-79 is active in preclinical models of arthritis. The chemical structure of ERB-79 does not appear to have been disclosed.

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dbo:abstract
  • ERB-79 is a synthetic estrogen and a selective agonist of the ERβ. It is a racemic mixture, with the active enantiomer being ERB-26. ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα. Its EC50 value for the ERβ is 0.448 nM (14.52% of the potency of estradiol) and for the ERα is 79 nM (0.03% of the potency of estradiol). It has no antagonistic activity at either receptor. ERB-79 is active in preclinical models of arthritis. The chemical structure of ERB-79 does not appear to have been disclosed. (en)
dbo:casNumber
  • 1807969-57-8
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  • 52741165 (xsd:integer)
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  • 991919054 (xsd:integer)
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dbp:casNumber
  • 1807969 (xsd:integer)
dbp:class
  • Estrogen; Selective ERβ agonist (en)
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rdfs:comment
  • ERB-79 is a synthetic estrogen and a selective agonist of the ERβ. It is a racemic mixture, with the active enantiomer being ERB-26. ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα. Its EC50 value for the ERβ is 0.448 nM (14.52% of the potency of estradiol) and for the ERα is 79 nM (0.03% of the potency of estradiol). It has no antagonistic activity at either receptor. ERB-79 is active in preclinical models of arthritis. The chemical structure of ERB-79 does not appear to have been disclosed. (en)
rdfs:label
  • ERB-79 (en)
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