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- Decapentaplegic (Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen. It is known to be necessary for the correct patterning and development of the early Drosophila embryo and the fifteen imaginal discs, which are tissues that will become limbs and other organs and structures in the adult fly. It has also been suggested that Dpp plays a role in regulating the growth and size of tissues. Flies with mutations in decapentaplegic fail to form these structures correctly, hence the name (decapenta-, fifteen, -plegic, paralysis). Dpp is the Drosophila homolog of the vertebrate bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily, a class of proteins that are often associated with their own specific signaling pathway. Studies of Dpp in Drosophila have led to greater understanding of the function and importance of their homologs in vertebrates like humans. (en)
- El gene decapentaplégico es un gen descubierto por el Dr. Gelbart y la proteína DPP se considera la homóloga de Drosophila a la proteína morfogénica ósea (BMP). Este gen participa en el desarrollo del eje dorso-ventral durante la formación del organismo. Participa en muchos procesos durante la morfogénesis en Drosophila, como en la diferenciación de venas, organización del disco genital, desarrollo del halterio, induce la proliferación celular, participan en la supervivencia y en apoptosis. Existen investigaciones que relacionan este gen junto al gen Wingless en la formación de tumores en Drosophila. Cuando las células que han entrado en apoptosis no pueden morir, emiten de forma permanente una serie de señales que inducen la proliferación celular. (es)
- Decapententaplegic缩写为Dpp，是果蝇皮肤的生长因子。它在皮肤表面影响着生物背部的颜色。 dpp基因从复制、转录到dpp蛋白的翻译过程如图所示。 如果DNA上的dpp基因发生突变，原来的G-C碱基对突变为A-T碱基对。将会导致最后转译出来的蛋白无法连接起来，从而引起皮肤的肤色发生改变。 (zh)
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- 25932 (xsd:nonNegativeInteger)
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- Drosophila melanogaster (en)
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- Decapententaplegic缩写为Dpp，是果蝇皮肤的生长因子。它在皮肤表面影响着生物背部的颜色。 dpp基因从复制、转录到dpp蛋白的翻译过程如图所示。 如果DNA上的dpp基因发生突变，原来的G-C碱基对突变为A-T碱基对。将会导致最后转译出来的蛋白无法连接起来，从而引起皮肤的肤色发生改变。 (zh)
- Decapentaplegic (Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen. It is known to be necessary for the correct patterning and development of the early Drosophila embryo and the fifteen imaginal discs, which are tissues that will become limbs and other organs and structures in the adult fly. It has also been suggested that Dpp plays a role in regulating the growth and size of tissues. Flies with mutations in decapentaplegic fail to form these structures correctly, hence the name (decapenta-, fifteen, -plegic, paralysis). Dpp is the Drosophila homolog of the vertebrate bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily, a class of proteins that are often associated with their (en)
- El gene decapentaplégico es un gen descubierto por el Dr. Gelbart y la proteína DPP se considera la homóloga de Drosophila a la proteína morfogénica ósea (BMP). Este gen participa en el desarrollo del eje dorso-ventral durante la formación del organismo. Participa en muchos procesos durante la morfogénesis en Drosophila, como en la diferenciación de venas, organización del disco genital, desarrollo del halterio, induce la proliferación celular, participan en la supervivencia y en apoptosis. (es)
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- Decapentaplegic (en)
- Decapentaplégico (es)
- Decapentaplegic (zh)
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