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- In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction dUTP + H2O dUMP + diphosphate Thus, the two substrates of this enzyme are and H2O, whereas its two products are dUMP and diphosphate. This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase. This enzyme participates in pyrimidine metabolism. This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair. (en)
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- 7453 (xsd:nonNegativeInteger)
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- crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms. (en)
- the crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp (en)
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- IPR008180 (en)
- IPR014871 (en)
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- dUTP diphosphatase (en)
- dUTPase (en)
- dUTPase_2 (en)
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| dbp:pfam
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- PF00692 (en)
- PF08761 (en)
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- 1 (xsd:integer)
- 6.31152E7
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- dUTPase (en)
- dUTPase_2 (en)
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| rdfs:comment
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- In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction dUTP + H2O dUMP + diphosphate Thus, the two substrates of this enzyme are and H2O, whereas its two products are dUMP and diphosphate. (en)
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