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- DNA Polymerase V (Pol V) is a polymerase enzyme involved in DNA repair mechanisms in bacteria, such as Escherichia coli. It is composed of a UmuD' homodimer and a UmuC monomer, forming the UmuD'2C protein complex. It is part of the Y-family of DNA Polymerases, which are capable of performing DNA translesion synthesis (TLS). Translesion polymerases bypass DNA damage lesions during DNA replication - if a lesion is not repaired or bypassed the replication fork can stall and lead to cell death. However, Y polymerases have low sequence fidelity during replication (prone to add wrong nucleotides). When the UmuC and UmuD' proteins were initially discovered in E. coli, they were thought to be agents that inhibit faithful DNA replication and caused DNA synthesis to have high mutation rates after exposure to UV-light. The polymerase function of Pol V was not discovered until the late 1990s when UmuC was successfully extracted, consequent experiments unequivocally proved UmuD'2C is a polymerase. This finding lead to the detection of many Pol V orthologs and the discovery of the Y-family of polymerases. (en)
- L'ADN polymérase V, ou pol V, est une ADN polymérase présente chez les bactéries et qui est impliquée dans la réparation de l'ADN dans le cadre des mécanismes de réparation SOS. Elle est apparentée à l'ADN polymérase IV, qui appartient comme elle à la famille Y des polymérases. (fr)
- La DNA polimerasi V è una DNA polimerasi procariotica coinvolta nella e nella riparazione del DNA per sintesi translesione.È simile alla : entrambe appartengono della famiglia-Y delle DNA polimerasi coinvolte nella risposta SOS nella riparazione del DNA per sintesi translesione.La trascrizione a partire dal gene umuDC è altamente regolata, e l'enzima è espresso solo quando è presente un danno al DNA cellulare tale da evocare la generazione della risposta SOS. (it)
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- 9695 (xsd:nonNegativeInteger)
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| dbp:chromosome
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- 2.700000 (xsd:double)
- 3.400000 (xsd:double)
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| dbp:entrezchromosome
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| dbp:entrezgene
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- 945746 (xsd:integer)
- 946359 (xsd:integer)
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| dbp:genlocEnd
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- 1230471 (xsd:integer)
- 1231866 (xsd:integer)
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| dbp:genlocStart
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- 1229926 (xsd:integer)
- 1230218 (xsd:integer)
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| dbp:name
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- DNA polymerase V, subunit C (en)
- DNA polymerase V, subunit D (en)
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| dbp:organism
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- Escherichia coli (en)
- (en)
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| dbp:refseqprotein
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- NP_415701.1 (en)
- NP_415702.1 (en)
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| rdfs:comment
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- L'ADN polymérase V, ou pol V, est une ADN polymérase présente chez les bactéries et qui est impliquée dans la réparation de l'ADN dans le cadre des mécanismes de réparation SOS. Elle est apparentée à l'ADN polymérase IV, qui appartient comme elle à la famille Y des polymérases. (fr)
- La DNA polimerasi V è una DNA polimerasi procariotica coinvolta nella e nella riparazione del DNA per sintesi translesione.È simile alla : entrambe appartengono della famiglia-Y delle DNA polimerasi coinvolte nella risposta SOS nella riparazione del DNA per sintesi translesione.La trascrizione a partire dal gene umuDC è altamente regolata, e l'enzima è espresso solo quando è presente un danno al DNA cellulare tale da evocare la generazione della risposta SOS. (it)
- DNA Polymerase V (Pol V) is a polymerase enzyme involved in DNA repair mechanisms in bacteria, such as Escherichia coli. It is composed of a UmuD' homodimer and a UmuC monomer, forming the UmuD'2C protein complex. It is part of the Y-family of DNA Polymerases, which are capable of performing DNA translesion synthesis (TLS). Translesion polymerases bypass DNA damage lesions during DNA replication - if a lesion is not repaired or bypassed the replication fork can stall and lead to cell death. However, Y polymerases have low sequence fidelity during replication (prone to add wrong nucleotides). When the UmuC and UmuD' proteins were initially discovered in E. coli, they were thought to be agents that inhibit faithful DNA replication and caused DNA synthesis to have high mutation rates after ex (en)
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| rdfs:label
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- DNA polymerase V (en)
- DNA polimerasi V (it)
- ADN polymérase V (fr)
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