BTRX-335140, also known by its other developmental code names BTRX-140, CYM-53093, and NMRA-140, is an opioid antagonist medication which is under development for the treatment of depression. It is specifically a selective κ-opioid receptor antagonist and is under development for major depressive disorder. As of February 2020, BTRX-335140 is in phase 2 clinical trials for this indication.
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