About: Benzamil

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org:8891

Benzamil or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results.

Property	Value
dbo:abstract	Benzamil or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results. (en)
dbo:iupacName	3,5-diamino-N-[(1E)-amino(benzylamino)methylidene]-6-chloropyrazine-2-carboxamide (en)
dbo:thumbnail	wiki-commons:Special:FilePath/Benzamil_structure.svg?width=300
dbo:wikiPageID	17192783 (xsd:integer)
dbo:wikiPageLength	5435 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1095792747 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Acylguanidines dbc:Aminopyrazines dbc:Potassium-sparing_diuretics dbr:Potassium dbr:Pyrazine dbr:Epithelial_sodium_channel dbr:Cystic_fibrosis dbr:Derivative_(chemistry) dbr:Triamterene dbr:Distal_convoluted_tubule dbr:Amiloride dbr:Benzyl dbr:Guanidine dbr:Hydrochloride dbr:Kidney dbr:Sodium dbr:Analog_(chemistry) dbr:ENaC dbr:File:Amilorid_-_Amiloride.svg
dbp:imagefile	Benzamil structure.svg (en)
dbp:imagesize	250 (xsd:integer)
dbp:iupacname	35 (xsd:integer)
dbp:verifiedrevid	413885315 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:wikiPageUsesTemplate	dbt:Diuretics dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Commonscatinline dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Cardiovascular-drug-stub dbt:Sodium_channel_blockers
dcterms:subject	dbc:Acylguanidines dbc:Aminopyrazines dbc:Potassium-sparing_diuretics
gold:hypernym	dbr:Blocker
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatMolecularFormulas yago:WikicatSodium-calciumExchangeBlockers yago:Abstraction100002137 yago:Athlete109820263 yago:Blocker109860248 yago:CausalAgent100007347 yago:Communication100033020 yago:Contestant109613191 yago:FootballPlayer110101634 yago:Formula106816935 yago:LivingThing100004258 yago:Message106598915 yago:MolecularFormula106817173 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:Player110439851 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:ChemicalCompound dbo:Drug yago:Statement106722453 yago:Whole100003553 umbel-rc:ChemicalSubstanceType
rdfs:comment	Benzamil or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results. (en)
rdfs:label	Benzamil (en)
owl:sameAs	freebase:Benzamil yago-res:Benzamil wikidata:Benzamil http://azb.dbpedia.org/resource/بنزامیل dbpedia-fa:Benzamil dbpedia-sh:Benzamil dbpedia-sr:Benzamil dbpedia-vi:Benzamil https://global.dbpedia.org/id/4XviF dbr:Benzamil
prov:wasDerivedFrom	wikipedia-en:Benzamil?oldid=1095792747&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Benzamil_structure.svg wiki-commons:Special:FilePath/Amilorid_-_Amiloride.svg
foaf:isPrimaryTopicOf	wikipedia-en:Benzamil
is dbo:wikiPageRedirects of	dbr:C13H14ClN7O dbr:Benzyl_amiloride
is dbo:wikiPageWikiLink of	dbr:C13H14ClN7O dbr:Amiloride dbr:Benzyl_amiloride
is foaf:primaryTopic of	wikipedia-en:Benzamil