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- 5-HT2C receptor agonists are a class of drugs that activate 5-HT2C receptors. They have been investigated for the treatment of a number of conditions including obesity, psychiatric disorders, sexual dysfunction and urinary incontinence. The 5-HT2C receptors are one of three subtypes that belong to the serotonin 5-HT2 receptor subfamily along with 5-HT2A and 5-HT2B receptors. The development of 5-HT2C agonists has been a major obstacle, because of severe side effects due to a lack of selectivity over 5-HT2A and 5-HT2B receptors. Activation of 5-HT2A receptors can induce hallucinations, and the activation of 5-HT2B receptors has been implicated in cardiac valvular insufficiency and possibly in pulmonary hypertension. (en)
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- Derivative 1 (en)
- Derivative 2 (en)
- Derivative 3 (en)
- Derivative 4 (en)
- Derivative 5 (en)
- Pyrazolo[3,4-d]pyrimidine core (en)
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- A potent mCPP derivative (en)
- Derivative 1 (en)
- Derivative 2 (en)
- Derivative 3 (en)
- Derivative 4 (en)
- Derivative 5 (en)
- Pyrazolo[3,4-d]pyrimidine core (en)
- mCPP (en)
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- Figure 5. Pyrazolo[3,4-d]pyrimidine derivatives. (en)
- Figure 7. mCPP and a potent derivative. (en)
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- 1 (xsd:integer)
- 5 (xsd:integer)
- -skeletal.svg (en)
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- Explain what SAR this sentence refers to. For example, 'The SAR for the agonist-receptor interaction was determined...' or 'The SAR of the interaction of A with B was determined...' (en)
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- 150 (xsd:integer)
- 200 (xsd:integer)
- (100 * 220 / 127) round 0 (en)
- (100 * 220 / 140) round 0 (en)
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- 5-HT2C receptor agonists are a class of drugs that activate 5-HT2C receptors. They have been investigated for the treatment of a number of conditions including obesity, psychiatric disorders, sexual dysfunction and urinary incontinence. (en)
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- 5-HT2C receptor agonist (en)
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-1,2,3,6-tetrahydropyridine)-skeletal.svg){kind=link}
piperazine-skeletal.svg){kind=link}
