The 2021 Drydene 400 was a NASCAR Cup Series race that was held on May 16, 2021, at Dover International Speedway in Dover, Delaware. Contested over 400 laps on the 1-mile (1.6 km) concrete speedway, it was the 13th race of the 2021 NASCAR Cup Series season. All of Hendrick Motorsports's cars finished in the top four with Alex Bowman taking the checkered flag, the first team to do so since Roush Racing at the 2005 Ford 400.