The 2021 season for Alpecin–Fenix was the 13th season in the team's existence, the third as a UCI ProTeam, and the second under the current name. As the best performing UCI ProTeam in the 2020 season, Alpecin–Fenix were guaranteed invitations to all events in the 2021 UCI World Tour. The team finished the season once again as the best UCI ProTeam, ensuring UCI World Tour invitations in 2022.