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- 20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling. These vascular and kidney effects of 20-HETE have been shown to be responsible for regulating blood pressure and blood flow to specific organs in rodents; genetic and preclinical studies suggest that 20-HETE may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Additionally the loss of its production appears to be one cause of the human neurological disease, Hereditary spastic paraplegia. Preclinical studies also suggest that the overproduction of 20-HETE may contribute to the progression of certain human cancers, particularly those of the breast. (en)
- 20-Hydroxyeicosatetraensäure, auch bekannt als 20-HETE, ist ein Metabolit der Arachidonsäure mit einem breiten Wirkspektrum, vor allem auf das Herz-Kreislauf-System und die Nieren. In physiologischer Weise ist 20-HETE an der Regulation des Blutdrucks und der Organdurchblutung beteiligt. Präklinische Studien legen eine Rolle von 20-HETE bei der Pathogenese von Herzinfarkten und Schlaganfällen nahe. Ein Verlust der Synthesefähigkeit von 20-HETE ist mit dem Auftreten der hereditären spastischen Paraplegien (HSP) assoziiert. Eine Überproduktion von 20-HETE kann zur Entstehung von Tumoren beitragen, insbesondere zu Mamma-Karzinomen. (de)
- L'acido 20-idrossiarachidonico o 20-idrossieicosatetraenoico (in sigla dall'inglese 20-HETE ) è un acido grasso con 20 atomi di carbonio, 4 doppi legami in posizione 5=6, 8=9, 11=12, 14=15 e un gruppo ossidrile sostituente in posizione 20. I doppi legami sono tutti in configurazione cis . Appartiene alla famiglia degli eicosanoidi, metaboliti strutturalmente correlati che condividono un meccanismo comune per l'attivazione delle cellule e un insieme comune di attività biologiche e conseguenti potenziali effetti sulla salute.Gli studi sugli animali e una serie limitata di studi sull'uomo suggeriscono che questa famiglia di metaboliti funga da agente di segnalazione autocrina e paracrina, simile agli ormoni, che contribuisce alla regolazione delle risposte fisiologiche. (it)
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- 20-HETE, 20-Hydroxy-5,8,11,14-eicosatetraenoic, 20-Hydroxyeicosatetraenoic acid (en)
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- (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid (en)
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- 80798 (xsd:nonNegativeInteger)
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- Chemical structure of 20-Hydroxyeicosatetraenoic acid.svg (en)
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- 20-Hydroxyeicosatetraensäure, auch bekannt als 20-HETE, ist ein Metabolit der Arachidonsäure mit einem breiten Wirkspektrum, vor allem auf das Herz-Kreislauf-System und die Nieren. In physiologischer Weise ist 20-HETE an der Regulation des Blutdrucks und der Organdurchblutung beteiligt. Präklinische Studien legen eine Rolle von 20-HETE bei der Pathogenese von Herzinfarkten und Schlaganfällen nahe. Ein Verlust der Synthesefähigkeit von 20-HETE ist mit dem Auftreten der hereditären spastischen Paraplegien (HSP) assoziiert. Eine Überproduktion von 20-HETE kann zur Entstehung von Tumoren beitragen, insbesondere zu Mamma-Karzinomen. (de)
- 20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling. These vascular and kidney effects of 20-HETE have been shown to be responsible for regulating blood pressure and blood flow to specific organs in rodents; genetic and preclinical studies suggest that 20-HETE may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Additionally the loss of its production appears to be one cause of the human neurological disease, Hereditary spastic paraplegia. Pr (en)
- L'acido 20-idrossiarachidonico o 20-idrossieicosatetraenoico (in sigla dall'inglese 20-HETE ) è un acido grasso con 20 atomi di carbonio, 4 doppi legami in posizione 5=6, 8=9, 11=12, 14=15 e un gruppo ossidrile sostituente in posizione 20. I doppi legami sono tutti in configurazione cis . (it)
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- 20-Hydroxyeicosatetraensäure (de)
- 20-Hydroxyeicosatetraenoic acid (en)
- Acido 20-idrossieicosatetraenoico (it)
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