The 1965 St. Louis Cardinals season was the team's 46th year in the National Football League (NFL) and their sixth season in St. Louis. After losing the season opener in Philadelphia, the Cardinals reeled off four consecutive wins to move into a tie with the Cleveland Browns at 4–1 after five weeks. However, the Cardinals lost their final six games to finish in sixth place at 5–9, ahead of only the 2–12 Pittsburgh Steelers in the NFL Eastern Conference.