The 1961 USC Trojans football team represented the University of Southern California (USC) in the 1961 NCAA University Division football season. In their second year under head coach John McKay, the Trojans compiled a 4–5–1 record (2–1–1 against conference opponents), finished in a tie for second place in the Athletic Association of Western Universities, and were outscored by their opponents by a combined total of 167 to 151.