The 1946 Colorado Buffaloes football team was an American football team that represented the University of Colorado as a member of the Mountain States Conference (MSC) during the 1946 college football season. In their fourth season under head coach James J. Yeager, he Buffaloes compiled a 5–4–1 record (3–2–1 against MSC opponents), tied for fourth place in the MSC, and were outscored by a total of 147 to 91.