The 1935 Michigan State Spartans football team represented Michigan State College as an independent during the 1935 college football season. In their third season under head coach Charlie Bachman, the Spartans compiled a 6–2 record and won their annual rivalry game with Michigan by a 25 to 6 score. In inter-sectional play, the team defeated Kansas (42–0) and the Loyola Lions (27–0) but lost to Boston College (18–6). Guard Sid Wagner was a consensus first-team player on the 1935 College Football All-America Team.