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Statements

Subject Item
dbr:QH-II-66
rdf:type
yago:Sedative104166553 yago:Sedative-hypnotic104166841 yago:MuscleRelaxant103800001 dbo:Drug yago:Substance100020090 yago:Relaxant104072811 yago:CausalAgent100007347 yago:DrugOfAbuse103248958 yago:Benzodiazepine102830852 yago:Drug103247620 yago:Matter100020827 wikidata:Q8386 yago:Medicine103740161 yago:Tranquilizer104470232 yago:WikicatSedatives yago:Hypnagogue114913744 yago:WikicatHypnotics yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:MinorTranquilizer103771443 owl:Thing yago:WikicatBenzodiazepines dbo:ChemicalSubstance yago:Soporific104260934 n23:ChemicalObject yago:Agent114778436
rdfs:label
QH-II-66 QH-II-66
rdfs:comment
QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects. QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. Il QH-II-66 è un sedativo appartenente alla categoria delle benzodiazepine. Produce alcuni degli stessi effetti delle altre benzodiazepine, ma è più selettivo della maggior parte degli altri farmaci di questa classe e quindi produce meno sedazione e atassia rispetto ad altri farmaci correlati come diazepam e triazolam, sebbene mantenga effetti anticonvulsivanti.
foaf:depiction
n12:QH-II-66.svg n12:Qhii663d.png
dcterms:subject
dbc:GABAA_receptor_positive_allosteric_modulators dbc:Ethynyl_compounds dbc:Lactams dbc:Hypnotics dbc:Sedatives dbc:Benzodiazepines
dbo:wikiPageID
13353724
dbo:wikiPageRevisionID
1123033643
dbo:wikiPageWikiLink
dbr:GABAA_receptor dbc:GABAA_receptor_positive_allosteric_modulators dbr:GL-II-73 dbr:Diazepam dbr:SH-053-R-CH3-2′F dbr:Benzodiazepine dbc:Ethynyl_compounds dbr:Triazolam dbr:Sedative dbc:Hypnotics dbc:Lactams dbr:SH-I-048A dbr:Alcoholic_beverage dbr:Inverse_agonist dbr:GABRA5 dbr:Anticonvulsant dbc:Sedatives dbr:Agonist dbr:Ataxia dbc:Benzodiazepines dbr:Ro15-4513 dbr:Gamma-aminobutyric_acid
owl:sameAs
dbpedia-it:QH-II-66 dbpedia-sr:QH-II-66 yago-res:QH-II-66 freebase:m.03c2mrp n20:4u7Lu dbpedia-sh:QH-II-66 wikidata:Q7265454
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dbo:thumbnail
n12:QH-II-66.svg?width=300
dbp:c
18
dbp:casNumber
183239
dbp:chembl
174535
dbp:chemspiderid
8014151
dbp:h
14
dbp:image
Qhii663d.png
dbp:iupacName
7
dbp:legalDe
NpSG
dbp:legalUk
PSA
dbp:molecularWeight
274.33
dbp:n
2
dbp:o
1
dbp:pubchem
9838431
dbp:smiles
O=C1NC2=CC=CC#C
dbp:stdinchi
1
dbp:stdinchikey
FESCSZDQOFYRDR-UHFFFAOYSA-N
dbp:unii
PKW6UCK55B
dbp:verifiedfields
changed
dbp:verifiedrevid
464378091
dbp:watchedfields
changed
dbp:width
200
dbo:abstract
Il QH-II-66 è un sedativo appartenente alla categoria delle benzodiazepine. Produce alcuni degli stessi effetti delle altre benzodiazepine, ma è più selettivo della maggior parte degli altri farmaci di questa classe e quindi produce meno sedazione e atassia rispetto ad altri farmaci correlati come diazepam e triazolam, sebbene mantenga effetti anticonvulsivanti. QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects. QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. The α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH-ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions. QH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5. The inverse agonist Ro15-4513, which blocks the α5 subtype of GABAA, reverses the effects of alcohol, suggesting that this subtype is also important in producing the subjective effects of alcohol intoxication.
dbp:legalCa
Schedule IV
gold:hypernym
dbr:Drug
prov:wasDerivedFrom
wikipedia-en:QH-II-66?oldid=1123033643&ns=0
dbo:wikiPageLength
6291
dbo:casNumber
183239-39-6
dbo:chEMBL
174535
dbo:fdaUniiCode
PKW6UCK55B
dbo:pubchem
9838431
foaf:isPrimaryTopicOf
wikipedia-en:QH-II-66
Subject Item
dbr:SH-I-048A
dbo:wikiPageWikiLink
dbr:QH-II-66
Subject Item
dbr:GABAA_receptor
dbo:wikiPageWikiLink
dbr:QH-II-66
Subject Item
dbr:GL-II-73
dbo:wikiPageWikiLink
dbr:QH-II-66
Subject Item
dbr:QH-ii-066
dbo:wikiPageWikiLink
dbr:QH-II-66
dbo:wikiPageRedirects
dbr:QH-II-66
Subject Item
wikipedia-en:QH-II-66
foaf:primaryTopic
dbr:QH-II-66