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Statements

Subject Item
dbr:Proliferative_fasciitis_and_proliferative_myositis
rdf:type
wikidata:Q12136 dbo:Disease owl:Thing
rdfs:label
Proliferative fasciitis and proliferative myositis
rdfs:comment
Proliferative fasciitis and proliferative myositis (PF/PM) are rare benign soft tissue lesions (i.e. a damaged or unspecified abnormal change in a tissue) that increase in size over several weeks and often regress over the ensuing 1–3 months. The lesions in PF/PM are typically obvious tumors or swellings. Historically, many studies had grouped the two descriptive forms of PF/PM as similar disorders with the exception that proliferative fasciitis occurs in subcutaneous tissues while proliferative myositis occurs in muscle tissues. In 2020, the World Health Organization agreed with this view and defined these lesions as virtually identical disorders termed proliferative fasciitis/proliferative myositis or proliferative fasciitis and proliferative myositis. The Organization also classified th
foaf:name
Proliferative fasciitis and proliferative myositis
dbp:name
Proliferative fasciitis and proliferative myositis
dcterms:subject
dbc:Connective_and_soft_tissue_neoplasms dbc:Benign_neoplasms
dbo:wikiPageID
68431457
dbo:wikiPageRevisionID
1076942061
dbo:wikiPageWikiLink
dbr:Jaw dbr:Giant-cell_tumor_of_bone dbr:Chromosomal_translocation dbr:Locus_(genetics) dbr:Oncogene dbr:Karyotype dbr:Subcutaneous_tissue dbr:Genes dbr:Trisomy dbc:Connective_and_soft_tissue_neoplasms dbr:Benign_tumor dbr:Dermatology dbr:Collagen_fiber dbr:Fibroblastic_and_myofibroblastic_tumors dbr:Muscle_tissue dbr:Radiation_therapy dbr:Muscles_of_mastication dbr:Limb_(anatomy) dbr:General_surgery dbr:Actin dbr:Malignancy dbr:Undifferentiated_pleomorphic_sarcoma dbr:Mitosis dbr:Basophilic dbr:Symptomatic_therapy dbr:Chromosome_6 dbr:Soft_tissue dbr:Ulcerated dbr:Histopathology dbr:Mucus dbr:Histopathological dbr:Fibroblastic dbr:C-Fos dbr:Nodular_fasciitis dbr:Necrosis dbr:Sarcoma dbr:Nonsteroidal_anti-inflammatory_drugs dbr:Lobulated dbr:Trismus dbc:Benign_neoplasms dbr:Fusion_gene dbr:Myositis_ossificans dbr:Surgery dbr:Vimentin dbr:Chemotherapy dbr:Vacuole dbr:Neoplasm dbr:Biopsied dbr:Ganglion_cell dbr:Cytoplasm dbr:Watchful_waiting dbr:Aneurysmal_bone_cyst dbr:H&E_staining dbr:Clone_(cell_biology) dbr:Rhabdomyosarcoma dbr:Torso dbr:Trigger_finger dbr:Amphophilic dbr:Metastasize dbr:Proliferative_index dbr:FOSB dbr:Fusion_protein dbr:Gene_expression dbr:Chromosome_2 dbr:Myofibroblast dbr:Chromosome_10 dbr:Chromosome_14 dbr:Epithelioid_cell
owl:sameAs
wikidata:Q108266561 n14:FunHK
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dbt:Reflist dbt:Infobox_medical_condition_(new)
dbp:onset
Very rapid
dbp:treatment
symptomatic therapy, watchful waiting, surgical resection
dbp:duration
Often regresses spontaneously within weeks of diagnosis
dbp:field
dbr:Dermatology dbr:General_surgery
dbp:frequency
Extremely rare
dbo:abstract
Proliferative fasciitis and proliferative myositis (PF/PM) are rare benign soft tissue lesions (i.e. a damaged or unspecified abnormal change in a tissue) that increase in size over several weeks and often regress over the ensuing 1–3 months. The lesions in PF/PM are typically obvious tumors or swellings. Historically, many studies had grouped the two descriptive forms of PF/PM as similar disorders with the exception that proliferative fasciitis occurs in subcutaneous tissues while proliferative myositis occurs in muscle tissues. In 2020, the World Health Organization agreed with this view and defined these lesions as virtually identical disorders termed proliferative fasciitis/proliferative myositis or proliferative fasciitis and proliferative myositis. The Organization also classified them as one of the various forms of the fibroblastic and myofibroblastic tumors. PF/PM lesions have been regarded as a tissue's self-limiting reaction to an injury or unidentified insult rather than an abnormal growth of a clone of neoplastic cells, that is, as a group of cells which share a common ancestry, have similar abnormalities in the expression and/or content of their genetic material, and often grow in a continuous and unrestrained manner. However, a recent study has found a common genetic abnormality in some of the cells in most PF/FM tumors. This suggests that PF/PM are, in at least most cases, neoplastic but nonetheless self-limiting and/or spontaneously reversing disorders. That is, they are examples of "transient neoplasms." In all events, PF/PM lesions are benign tumor growths that do not metastasize. PF/PM lesions may grow at alarming rates, exhibit abnormal histopathologies (e.g. high numbers and overcrowding of cells), and have other elements that are suggestive of a malignancy. Consequently, they have been mistakenly diagnosed as undifferentiated pleomorphic sarcoma (also termed malignant fibrous histiocytoma), rhabdomyosarcoma, or other types of sarcoma and treated unnecessarily with aggressive measures used for such malignancies, e.g. wide surgical resection, radiation therapy, and chemotherapy. The majority of PF/PM lesions are successfully treated with strictly conservative and supportive measures.
dbp:prognosis
Excellent
dbo:treatment
dbr:Surgery dbr:Watchful_waiting dbr:Symptomatic_therapy
prov:wasDerivedFrom
wikipedia-en:Proliferative_fasciitis_and_proliferative_myositis?oldid=1076942061&ns=0
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19838
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wikipedia-en:Proliferative_fasciitis_and_proliferative_myositis
Subject Item
dbr:Ischemic_fasciitis
dbo:wikiPageWikiLink
dbr:Proliferative_fasciitis_and_proliferative_myositis
Subject Item
dbr:Acral_myxoinflammatory_fibroblastic_sarcoma
dbo:wikiPageWikiLink
dbr:Proliferative_fasciitis_and_proliferative_myositis
Subject Item
dbr:Fibroblastic_and_myofibroblastic_tumors
dbo:wikiPageWikiLink
dbr:Proliferative_fasciitis_and_proliferative_myositis
Subject Item
wikipedia-en:Proliferative_fasciitis_and_proliferative_myositis
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dbr:Proliferative_fasciitis_and_proliferative_myositis