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Statements

Subject Item
dbr:Horizontal_transfer_of_mitochondria
rdfs:label
Horizontal transfer of mitochondria
rdfs:comment
Horizontal transfer of mitochondria is the movement of whole mitochondria and mitochondrial DNA between cells. Mitochondria from donor cells are transported and incorporated into the endogenous mitochondrial network of recipient cells contributing to changes in the bioenergetics profile and in other functional properties of recipient cells. Horizontal cell-to-cell transfer of mitochondria and mitochondrial genome can occur among mammalian cells in vitro and in vivo. Mitochondrial transfer supports the exogenous replacement of damaged mitochondria, thereby rescuing mitochondrial defects. Stem cells, immortalized cells or primary cells are usually used as mitochondrial donors in most studies. These cells may transfer mitochondria to surrounding cells in their niche, thus affecting cell diffe
dcterms:subject
dbc:Mitochondria dbc:Cell_anatomy
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61072683
dbo:wikiPageRevisionID
1064781131
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dbr:In_vitro dbr:Endogenous dbr:In_vivo dbc:Cell_anatomy dbr:Immortalised_cell_line dbr:Mitochondria dbr:Tunneling_nanotubes dbr:Canine_transmissible_venereal_tumor dbc:Mitochondria dbr:Mitochondrial_DNA
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dbo:abstract
Horizontal transfer of mitochondria is the movement of whole mitochondria and mitochondrial DNA between cells. Mitochondria from donor cells are transported and incorporated into the endogenous mitochondrial network of recipient cells contributing to changes in the bioenergetics profile and in other functional properties of recipient cells. Horizontal cell-to-cell transfer of mitochondria and mitochondrial genome can occur among mammalian cells in vitro and in vivo. Mitochondrial transfer supports the exogenous replacement of damaged mitochondria, thereby rescuing mitochondrial defects. Stem cells, immortalized cells or primary cells are usually used as mitochondrial donors in most studies. These cells may transfer mitochondria to surrounding cells in their niche, thus affecting cell differentiation, proliferation, tissue homeostasis, development and ageing.
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dbr:Tunneling_nanotube
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dbr:Horizontal_transfer_of_mitochondria
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wikipedia-en:Horizontal_transfer_of_mitochondria
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