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Statements

Subject Item
dbr:Gap_Junction_Modulation
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dbr:Gap_junction_modulation
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Gap junction modulation
rdfs:comment
Gap junction modulation describes the functional manipulation of gap junctions, specialized channels that allow direct electrical and chemical communication between cells without exporting material from the cytoplasm. Gap junctions play an important regulatory role in various physiological processes including signal propagation in cardiac muscles and tissue homeostasis of the liver. Modulation is required, since gap junctions must respond to their environment, whether through an increased expression or permeability. Impaired or altered modulation can have significant health implications and are associated with the pathogenesis of the liver, heart and intestines.
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1121417081
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dbr:Diarrhea dbr:Ion dbr:Plakophilin-2 dbr:Ubiquitin dbr:Calcium dbr:Liver_failure n8:2017abc_Cardiac_Muscle.jpg dbr:GJA1 dbr:Inflammation dbr:Tight_junction dbr:Functional_group dbr:Lipophile dbr:Heart dbr:Junctional_complex dbr:CDH2 dbr:Nitrosylation dbr:Protein dbr:Protein_kinase_G dbr:Connexon dbr:Vinnexin dbr:Cardiac_muscle dbr:Globular_protein dbr:Inflammatory_bowel_disease dbr:Endogeny_(biology) dbr:Cyclic_adenosine_monophosphate dbr:Amine dbr:Cytoplasm dbr:Hemichannel dbr:Liver dbr:Tyrosine_kinase dbr:PH dbr:Endoplasmic_reticulum dbr:Hormone dbr:Covalent_bond dbr:Positive_feedback dbr:Connexin dbc:Cell_communication dbr:Passive_transport dbr:Endoplasmic-reticulum-associated_protein_degradation dbr:Arrhythmogenic_cardiomyopathy dbr:Translation_(biology) dbr:Protein_kinase_C dbr:Cell_membrane dbr:Electrochemical_gradient dbr:Smooth_muscle dbr:Organism dbr:Depolarization dbr:CAMP-dependent_protein_kinase_A dbr:Sodium_ion_channels dbr:Substrate_(biology) dbr:Hydroxylation dbr:Endocytosis dbr:Hypoxia_(medical) dbr:Calmodulin dbr:Deamidation dbr:Homeostasis dbr:Calcium_channel n8:Figure_04_06_05.jpg dbr:Hyperpolarization_(biology) dbr:Growth_factor dbr:Gap_junction dbr:Phosphorylation dbr:Mitogen-activated_protein_kinase dbr:Oligomerization dbr:Casein_kinase dbr:Potassium_channel dbr:Cation dbr:Cirrhosis dbr:Golgi_apparatus n17:threonine-specific_protein_kinase dbr:Proteasome dbr:Amino_acid dbr:Intestines dbr:Apoptosis dbr:Acute_liver_failure
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dbo:abstract
Gap junction modulation describes the functional manipulation of gap junctions, specialized channels that allow direct electrical and chemical communication between cells without exporting material from the cytoplasm. Gap junctions play an important regulatory role in various physiological processes including signal propagation in cardiac muscles and tissue homeostasis of the liver. Modulation is required, since gap junctions must respond to their environment, whether through an increased expression or permeability. Impaired or altered modulation can have significant health implications and are associated with the pathogenesis of the liver, heart and intestines. Modulation is achieved by endogenous chemicals, growth factors, hormones and proteins that affect gap junction expression, structure, degradation and permeability. Natural forms of modulation include voltage gating and chemical modulation. Voltage-gating is a relatively fast modulation categorized into Vj gating and slow voltage gating, which are further influenced by calcium ions (Ca2+), pH and calmodulin. Chemical modulation entails the addition or removal of a functional group or protein from the connexin subunits of gap junctions; this can alter gap junction expression and structure.
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