This HTML5 document contains 72 embedded RDF statements represented using HTML+Microdata notation.

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Statements

Subject Item
dbr:Zindoxifene
dbo:wikiPageWikiLink
dbr:D-15414
Subject Item
dbr:2-Phenylindole
dbo:wikiPageWikiLink
dbr:D-15414
Subject Item
dbr:D-15414
rdf:type
n7:ChemicalObject owl:Thing dbo:ChemicalSubstance dbo:Drug wikidata:Q8386
rdfs:label
D-15414
rdfs:comment
D-15414 is a nonsteroidal weak estrogen of the 2-phenylindole group which was never marketed. It is the major metabolite of the selective estrogen receptor modulator (SERM) zindoxifene (D-16726). D-15414 has high affinity for the estrogen receptor (ER) and inhibits the growth of ER-positive MCF-7 breast cancer cells in vitro. However, contradictorily, subsequent research found that the drug produced fully estrogenic effects in vitro similarly to but less actively than estradiol, with no antiestrogenic activity observed. The reason for the discrepancy between the findings is unclear, though may be due to methodology. The unexpected estrogenic activity of D-15414 may be responsible for the failure of zindoxifene in clinical trials as a treatment for breast cancer.
foaf:depiction
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dcterms:subject
dbc:Indoles dbc:Synthetic_estrogens dbc:Abandoned_drugs
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53754424
dbo:wikiPageRevisionID
1073990994
dbo:wikiPageWikiLink
dbr:Nonsteroidal dbr:Estrogen dbr:MCF-7 dbr:Estrogen_receptor dbr:Metabolite dbr:Zindoxifene dbr:In_vitro dbr:Methodology dbr:2-phenylindole dbc:Indoles dbc:Synthetic_estrogens dbr:Cell_(biology) dbr:Clinical_trial dbr:Selective_estrogen_receptor_modulator dbr:Affinity_(pharmacology) dbr:Antiestrogen dbr:Estradiol dbc:Abandoned_drugs dbr:Breast_cancer
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dbo:thumbnail
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dbp:c
17
dbp:casNumber
86111
dbp:chembl
287232
dbp:chemspiderid
114137
dbp:h
17
dbp:iupacName
1
dbp:n
1
dbp:o
2
dbp:pubchem
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dbp:smiles
CCN1C2=CCC
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1
dbp:stdinchikey
BXTNOIWYTWIPEL-UHFFFAOYSA-N
dbp:unii
58
dbp:width
250
dbo:abstract
D-15414 is a nonsteroidal weak estrogen of the 2-phenylindole group which was never marketed. It is the major metabolite of the selective estrogen receptor modulator (SERM) zindoxifene (D-16726). D-15414 has high affinity for the estrogen receptor (ER) and inhibits the growth of ER-positive MCF-7 breast cancer cells in vitro. However, contradictorily, subsequent research found that the drug produced fully estrogenic effects in vitro similarly to but less actively than estradiol, with no antiestrogenic activity observed. The reason for the discrepancy between the findings is unclear, though may be due to methodology. The unexpected estrogenic activity of D-15414 may be responsible for the failure of zindoxifene in clinical trials as a treatment for breast cancer.
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3977
dbo:casNumber
86111-11-7
dbo:chEMBL
287232
dbo:fdaUniiCode
58AE9Z8TW6
dbo:pubchem
128800
foaf:isPrimaryTopicOf
wikipedia-en:D-15414
Subject Item
dbr:C17H17NO2
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Subject Item
dbr:D15414
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dbr:D-15414
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dbr:D_15414
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dbr:D-15414