About: Zindoxifene

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed. It showed estrogenic-like activity in preclinical studies and failed to demonstrate effectiveness as a treatment for breast cancer in clinical trials. Zindoxifene was the lead compound of the distinct 2-phenylindole class of SERMs, and the marketed SERM bazedoxifene was derived from the major active metabolite of zindoxifene, D-15414. Zindoxifene was first described in 1984.

Property	Value
dbo:abstract	Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed. It showed estrogenic-like activity in preclinical studies and failed to demonstrate effectiveness as a treatment for breast cancer in clinical trials. Zindoxifene was the lead compound of the distinct 2-phenylindole class of SERMs, and the marketed SERM bazedoxifene was derived from the major active metabolite of zindoxifene, D-15414. Zindoxifene was first described in 1984. (en)
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dbo:chEBI	35052
dbo:chEMBL	32227
dbo:fdaUniiCode	1IRS95M8DN
dbo:kegg	C14745
dbo:pubchem	65645
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dbp:iupacName	[4-phenyl] acetate (en)
dbp:kegg	14745.0
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dbp:pubchem	65645 (xsd:integer)
dbp:smiles	CCN1C2=CCC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	KSZGVNZSUJHOJA-UHFFFAOYSA-N (en)
dbp:synonyms	D-16726; NSC-341952 (en)
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rdfs:comment	Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed. It showed estrogenic-like activity in preclinical studies and failed to demonstrate effectiveness as a treatment for breast cancer in clinical trials. Zindoxifene was the lead compound of the distinct 2-phenylindole class of SERMs, and the marketed SERM bazedoxifene was derived from the major active metabolite of zindoxifene, D-15414. Zindoxifene was first described in 1984. (en)
rdfs:label	Zindoxifene (en)
owl:sameAs	yago-res:Zindoxifene wikidata:Zindoxifene https://global.dbpedia.org/id/2YBZ4
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