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Statements

Subject Item
dbr:Enediyne
dbo:wikiPageWikiLink
dbr:C-1027
Subject Item
dbr:C-1027
rdf:type
wikidata:Q11173 owl:Thing dbo:ChemicalCompound n17:ChemicalObject dbo:ChemicalSubstance
rdfs:label
C-1027
rdfs:comment
C-1027 or Lidamycin is an antitumor antibiotic consisting of a complex of an enediyne chromophore and an apoprotein. It shows antibiotic activity against most Gram-positive bacteria. It is one of the most potent cytotoxic molecules known, due to its induction of a higher ratio of DNA double-strand breaks than single-strand breaks.
foaf:name
C-1027 chromophore
dbp:name
C-1027 chromophore
foaf:depiction
n15:C-1027_mechanism.png n15:C‐1027_chromophore.svg
dcterms:subject
dbc:Nine-membered_rings dbc:Antibiotics dbc:Enediynes dbc:Vinylidene_compounds dbc:Experimental_cancer_drugs
dbo:wikiPageID
57337376
dbo:wikiPageRevisionID
1107519240
dbo:wikiPageWikiLink
n4:C-1027_mechanism.png dbc:Nine-membered_rings dbr:Biological_activity dbr:Gram-positive_bacteria dbc:Enediynes dbc:Antibiotics dbr:Antibiotic dbr:Antitumor dbr:Apoptosis dbr:Tumor_hypoxia dbr:Enediyne dbr:Apoenzyme dbc:Experimental_cancer_drugs dbc:Vinylidene_compounds dbr:Cytotoxic dbr:Chromophore dbr:Phase_II_clinical_trial dbr:Diradical
owl:sameAs
n11:2XrCE wikidata:Q27136818
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dbt:Chembox_Properties dbt:Chembox_Identifiers dbt:Chembox dbt:Oncology-stub dbt:Antibiotic-stub dbt:Reflist dbt:Enediynes
dbo:thumbnail
n15:C‐1027_chromophore.svg?width=300
dbp:imagefile
C‐1027 chromophore.svg
dbp:imagesize
200
dbp:iupacname
-22
dbp:othernames
Lidamycin chromophore
dbo:abstract
C-1027 or Lidamycin is an antitumor antibiotic consisting of a complex of an enediyne chromophore and an apoprotein. It shows antibiotic activity against most Gram-positive bacteria. It is one of the most potent cytotoxic molecules known, due to its induction of a higher ratio of DNA double-strand breaks than single-strand breaks. C-1027's chromophore contains a nine-membered enediyne that is responsible for most of the molecule's biological activity. Unlike other enediynes, this molecule contains no triggering mechanism. It is already primed to undergo the cycloaromatization reaction without external activation to produce the toxic 1,4-benzenoid diradical species. C-1027 can induce oxygen-independent interstrand DNA crosslinks in addition to the oxygen-dependent single- and double-stranded DNA breaks typically generated by other enediynes. This unique oxygen-independent mechanism suggests that C-1027 may be effective against hypoxic tumor cells. C-1027 shows promise as an anticancer drug and is currently undergoing phase II clinical trials in China, with a 30% success rate. It can induce apoptosis in many cancer cells and recent studies have indicated that it induces unusual DNA damage responses to double-strand breaks, including altering cell cycle progression and inducing chromosomal aberrations.
prov:wasDerivedFrom
wikipedia-en:C-1027?oldid=1107519240&ns=0
dbo:wikiPageLength
7535
dbo:alternativeName
Lidamycin chromophore
dbo:iupacName
(3R,4R,14R,19S)-22-chloro-4-{[(2S,3R,4R,5S)-5-(dimethylamino)-3,4-dihydroxy-6,6-dimethyloxan-2-yl]oxy}-23-hydroxy-14-(3-hydroxy-7-methoxy-2-methylidene-2H-1,4-benzoxazine-5-carbonyloxy)-17-oxo-2,16-dioxapentacyclo[18.2.2.19,13.03,10.04,8]pentacosa-1(22),5,7,9,11,13(25),20,23-octaen-19-aminium
foaf:isPrimaryTopicOf
wikipedia-en:C-1027
Subject Item
dbr:C43H42ClN3O13
dbo:wikiPageWikiLink
dbr:C-1027
dbo:wikiPageRedirects
dbr:C-1027
Subject Item
dbr:Kedarcidin
dbo:wikiPageWikiLink
dbr:C-1027
Subject Item
dbr:Streptomyces_globisporus
dbo:wikiPageWikiLink
dbr:C-1027
Subject Item
dbr:Lidamycin
dbo:wikiPageWikiLink
dbr:C-1027
dbo:wikiPageRedirects
dbr:C-1027
Subject Item
wikipedia-en:C-1027
foaf:primaryTopic
dbr:C-1027