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Statements

Subject Item
dbr:Meir_Wilchek
dbo:wikiPageWikiLink
dbr:Affinity_label
Subject Item
dbr:John_Katzenellenbogen
dbo:wikiPageWikiLink
dbr:Affinity_label
Subject Item
dbr:Finn_Wold
dbo:wikiPageWikiLink
dbr:Affinity_label
Subject Item
dbr:Affinity_label
rdf:type
yago:OrganicCompound114727670 yago:Protein114728724 yago:Part113809207 yago:Relation100031921 owl:Thing yago:Abstraction100002137 yago:Chemical114806838 yago:Molecule114682133 yago:Compound114818238 yago:Thing100002452 yago:PhysicalEntity100001930 yago:Enzyme114732946 yago:Activator114723079 yago:Catalyst114723628 dbo:Protein yago:Material114580897 yago:Matter100020827 yago:Unit109465459 yago:Substance100019613 yago:Macromolecule114944888 yago:WikicatEnzymes
rdfs:label
Affinity label
rdfs:comment
Affinity labels are a class of enzyme inhibitors that covalently bind to their target causing its inactivation. The hallmark of an affinity label is the use of a targeting moiety to specifically and reversibly deliver a weakly reactive group to the enzyme that irreversibly binds to an amino acid residue. The targeting portion of the label often resembles the enzyme's natural substrate so that a similar mode of noncovalent binding is used prior to the covalent linkage. Their usefulness in medicine can be limited by the specificity of the first noncovalent binding step whereas indiscriminate action can be utilized for purposes such as affinity labeling - a technique for the validation of substrate-specific binding of compounds.
dcterms:subject
dbc:Enzymes
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2653621
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1108550329
dbo:wikiPageWikiLink
dbr:Effective_molarity dbr:Enzyme_inhibitor dbr:Electrophile dbr:Antibodies dbr:Afatinib dbr:Suicide_inhibition dbr:Cofactor_(biochemistry) dbr:Ribozyme dbc:Enzymes dbr:Azide-alkyne_Huisgen_cycloaddition dbr:Activity_based_proteomics dbr:Covalent_bond
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yago-res:Affinity_label n15:4LwPr wikidata:Q4688981 freebase:m.07vmpt
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dbo:abstract
Affinity labels are a class of enzyme inhibitors that covalently bind to their target causing its inactivation. The hallmark of an affinity label is the use of a targeting moiety to specifically and reversibly deliver a weakly reactive group to the enzyme that irreversibly binds to an amino acid residue. The targeting portion of the label often resembles the enzyme's natural substrate so that a similar mode of noncovalent binding is used prior to the covalent linkage. Their usefulness in medicine can be limited by the specificity of the first noncovalent binding step whereas indiscriminate action can be utilized for purposes such as affinity labeling - a technique for the validation of substrate-specific binding of compounds. These labels are not limited to enzymes but may also be designed to react with antibodies or ribozymes although this usage is less common. Although proteins such as hemoglobin do not have an active site, binding pockets can be exploited for their affinity and thus be labeled.
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wikipedia-en:Affinity_label?oldid=1108550329&ns=0
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8666
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wikipedia-en:Affinity_label
Subject Item
dbr:Ribosome
dbo:wikiPageWikiLink
dbr:Affinity_label
Subject Item
dbr:Affinity_labeling
dbo:wikiPageWikiLink
dbr:Affinity_label
dbo:wikiPageRedirects
dbr:Affinity_label
Subject Item
dbr:Affinity_labels
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dbr:Affinity_label
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dbr:Affinity_label
Subject Item
wikipedia-en:Affinity_label
foaf:primaryTopic
dbr:Affinity_label