About: Turosteride

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH), but was never marketed. Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. In animal studies it has been shown to inhibit prostate size and retard tumor growth. It may also be useful for the treatment of acne and hair loss.

Property Value
dbo:abstract
  • La turosteride è un farmaco di sintesi che agisce negli uomini inibendo l'enzima della 5-alfa reduttasi e che è sottoposto a sperimentazione umana per il trattamento dell'ipertrofia prostatica benigna, ma che non è ancora stato messo in commercio. (it)
  • Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH), but was never marketed. Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. In animal studies it has been shown to inhibit prostate size and retard tumor growth. It may also be useful for the treatment of acne and hair loss. (en)
dbo:casNumber
  • 137099-09-3
dbo:fdaUniiCode
  • LU1LTK666W
dbo:pubchem
  • 65986
dbo:thumbnail
dbo:wikiPageID
  • 26849255 (xsd:integer)
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  • 5155 (xsd:nonNegativeInteger)
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  • 1099104107 (xsd:integer)
dbo:wikiPageWikiLink
dbp:atcPrefix
  • none (en)
dbp:c
  • 27 (xsd:integer)
dbp:casNumber
  • 137099 (xsd:integer)
dbp:chemspiderid
  • 59380 (xsd:integer)
dbp:h
  • 45 (xsd:integer)
dbp:iupacName
  • (-1,4a,6a-trimethyl-2-oxo-N--N-hexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide) (en)
dbp:legalStatus
  • Never marketed (en)
dbp:n
  • 3 (xsd:integer)
dbp:o
  • 3 (xsd:integer)
dbp:pubchem
  • 65986 (xsd:integer)
dbp:routesOfAdministration
  • Oral (en)
dbp:smiles
  • O=CNCC (en)
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  • 1 (xsd:integer)
dbp:stdinchikey
  • WMPQMBUXZHMEFZ-YJPJVVPASA-N (en)
dbp:synonyms
  • (1--1,3- diisopropylurea) (en)
dbp:unii
  • LU1LTK666W (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • La turosteride è un farmaco di sintesi che agisce negli uomini inibendo l'enzima della 5-alfa reduttasi e che è sottoposto a sperimentazione umana per il trattamento dell'ipertrofia prostatica benigna, ma che non è ancora stato messo in commercio. (it)
  • Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH), but was never marketed. Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. In animal studies it has been shown to inhibit prostate size and retard tumor growth. It may also be useful for the treatment of acne and hair loss. (en)
rdfs:label
  • Turosteride (it)
  • Turosteride (en)
owl:sameAs
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