About: Toceranib

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug approved by the U.S. Food and Drug Administration (FDA). It is sold under the brand name Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654, a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect.

Property	Value
dbo:abstract	Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug approved by the U.S. Food and Drug Administration (FDA). It is sold under the brand name Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654, a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect. (en)
dbo:alternativeName	Palladia (en)
dbo:bioavailability	77.000000 (xsd:float)
dbo:casNumber	356068-94-5 874819-74-6
dbo:chEMBL	13608 2103833
dbo:class	dbr:Antineoplastic_agent
dbo:fdaUniiCode	24F9PF7J3R 59L7Y0530C
dbo:kegg	D08503 D08544
dbo:pubchem	5329106
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dbo:wikiPageExternalLink	https://druginfo.nlm.nih.gov/drugportal/name/toceranib
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dbp:alt	Ball-and-stick model of the toceranib molecule (en)
dbp:atcPrefix	L01 (en)
dbp:atcSuffix	EX90 (en)
dbp:atcvet	yes (en)
dbp:bioavailability	77.0
dbp:c	22 (xsd:integer)
dbp:casNumber	356068 (xsd:integer) 874819 (xsd:integer)
dbp:chembl	13608 (xsd:integer) 2103833 (xsd:integer)
dbp:chemspiderid	4486268 (xsd:integer) 13163443 (xsd:integer)
dbp:class	dbr:Antineoplastic_agent
dbp:dailymedid	Toceranib (en)
dbp:eliminationHalfLife	57600.0
dbp:f	1 (xsd:integer)
dbp:h	25 (xsd:integer)
dbp:image	Toceranib molecule ball.png (en)
dbp:index2Label	as salt (en)
dbp:iupacName	5 (xsd:integer)
dbp:kegg	D08503 (en) D08544 (en)
dbp:legalCa	Rx-only (en)
dbp:legalUs	Rx-only (en)
dbp:n	4 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pdbLigand	BWC (en)
dbp:proteinBound	91 (xsd:integer)
dbp:pubchem	5329106 (xsd:integer) 16034840 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:smiles	Fc1ccc2c/C=C/c4cC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	SRSGVKWWVXWSJT-ATVHPVEESA-N (en)
dbp:tradename	Palladia (en)
dbp:unii	24 (xsd:integer) 59 (xsd:integer)
dbp:width	260 (xsd:integer)
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dcterms:subject	dbc:Fluoroarenes dbc:Indoles dbc:Pfizer_brands dbc:Pyrrolidines dbc:Carboxamides dbc:Pyrroles dbc:Receptor_tyrosine_kinase_inhibitors dbc:Dog_medications
gold:hypernym	dbr:Inhibitor
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rdfs:comment	Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug approved by the U.S. Food and Drug Administration (FDA). It is sold under the brand name Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654, a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect. (en)
rdfs:label	Toceranib (en)
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