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- In medical imaging, a time-activity curve is a curve of radioactivity (in terms of concentration) plotted on the y-axis against the time plotted on the x-axis. It shows the concentration of a radiotracer within a region of interest in an image, measured over time from a dynamic scan. Generally, when a time-activity curve is obtained within a tissue, it is called as a tissue time-activity curve, which represents the concentration of tracer within a region of interest inside a tissue over time. Modern kinetic analysis is performed in various medical imaging techniques, which requires a tissue time-activity curve as one of the inputs to the mathematical model, for example, in dynamic positron emission tomography (PET) imaging, or perfusion CT, or dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a dynamic scan. A dynamic scan is a scan where two dimensional (2D) or three dimensional (3D) images are acquired again and again over a time-period forming a time-series of 2D/3D image datasets. For example, a dynamic contrast-enhanced magnetic resonance imaging scan acquired over ten minutes contains short image frames acquired for 30 seconds duration to capture the fast dynamics of gadolinium tracer. Each data-point in the time-activity curve represents a measurement of tracer-concentration from the region segmented on each of these image time-frame acquired over time. (en)
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- In medical imaging, a time-activity curve is a curve of radioactivity (in terms of concentration) plotted on the y-axis against the time plotted on the x-axis. It shows the concentration of a radiotracer within a region of interest in an image, measured over time from a dynamic scan. Generally, when a time-activity curve is obtained within a tissue, it is called as a tissue time-activity curve, which represents the concentration of tracer within a region of interest inside a tissue over time. (en)
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