About: Tifluadom

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite.

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dbo:abstract
  • Tifluadom ist ein nicht therapeutisch genutztes Benzodiazepin-Derivat mit einem für diese Substanzklasse abnormen Wirkmechanismus. (de)
  • Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite. While tifluadom has several effects which might have potential uses in medicine, such as analgesia and appetite stimulation, κ-opioid agonists tend to produce undesirable effects in humans such as dysphoria and hallucinations, and so these drugs tend to only be used in scientific research. Dysphoric effects are similar to those seen when using other κ-opioid receptor agonists like pentazocine and salvinorin A, and can be considered the opposite of morphine-induced euphoria. As such, kappa agonists are believed to have very limited abuse potential. (en)
  • Il tifluadom è uno psicofarmaco appartenente alla categoria delle benzodiazepine. A differenza della maggior parte delle benzodiazepine, il tifluadom non ha attività sul recettore GABA A , ma è invece un agonista selettivo per il recettore kappa oppioide. Il farmaco ha potenti effetti analgesici, diuretici negli animali, sedativi e stimola l'appetito. Ha inoltre degli effetti sul comportamento dei ratti che possono essere contrastati con la somministrazione di Naloxone. (it)
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  • 83386-35-0
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  • 169703
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  • TF8X866L0I
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  • 115208
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  • N-5-(2-Fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]thiophene-3-carboxamide (en)
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  • Tifluadom ist ein nicht therapeutisch genutztes Benzodiazepin-Derivat mit einem für diese Substanzklasse abnormen Wirkmechanismus. (de)
  • Il tifluadom è uno psicofarmaco appartenente alla categoria delle benzodiazepine. A differenza della maggior parte delle benzodiazepine, il tifluadom non ha attività sul recettore GABA A , ma è invece un agonista selettivo per il recettore kappa oppioide. Il farmaco ha potenti effetti analgesici, diuretici negli animali, sedativi e stimola l'appetito. Ha inoltre degli effetti sul comportamento dei ratti che possono essere contrastati con la somministrazione di Naloxone. (it)
  • Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite. (en)
rdfs:label
  • Tifluadom (de)
  • Tifluadom (it)
  • Tifluadom (en)
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