About: TRIMU 5

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation.

Property	Value
dbo:abstract	TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation. (en) Il TRIMU 5 è un agonista selettivo dei recettori μ-oppioidi tipo 2. (it)
dbo:iupacName	(L)-tyrosyl-N-{[(3-methylbutyl)amino]acetyl}-(D)-alaninamide (en) (2R)-2-Amino-3-(4-hydroxyphenyl)-N-[(2R)-1-{2-[(3-methylbutyl)amino]acetamido}-1-oxopropan-2-yl]propanamide (en)
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dbp:imagefile	TRIMU 5.png (en)
dbp:iupacname	(L)-tyrosyl-N-{[amino]acetyl}-(D)-alaninamide (en)
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rdfs:comment	TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation. (en) Il TRIMU 5 è un agonista selettivo dei recettori μ-oppioidi tipo 2. (it)
rdfs:label	TRIMU 5 (it) TRIMU 5 (en)
owl:sameAs	freebase:TRIMU 5 yago-res:TRIMU 5 wikidata:TRIMU 5 dbpedia-it:TRIMU 5 dbpedia-sh:TRIMU 5 dbpedia-sr:TRIMU 5 https://global.dbpedia.org/id/4vkFE
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