Sugar and Spies is a 1966 Warner Bros. Looney Tunes cartoon. The short was released on November 5, 1966, and stars Wile E. Coyote and the Road Runner. It is the second of two Road Runner shorts directed by Robert McKimson and the only one to feature music by Walter Greene. It is also the final appearance of the Road Runner and Wile E. Coyote during the Golden age of American animation. The title of the cartoon is a play on the term "sugar and spice".