| dbo:abstract
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- Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a heterobifunctional amine-to-sulfhydryl crosslinker, which contains two reactive groups at opposite ends: N-hydroxysuccinimide-ester and maleimide, reactive with amines and thiols respectively. SMCC is often used in bioconjugation to link proteins with other functional entities (fluorescent dyes, tracers, nanoparticles, cytotoxic agents). For example, a targeted anticancer agent – trastuzumab emtansine (antibody-drug conjugate containing an antibody trastuzumab chemically linked to a highly potent drug DM-1) – is prepared using SMCC reagent. (en)
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| dbo:alternativeName
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- SMCC, 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-succinimidyl ester (en)
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- Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (en)
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- 2453 (xsd:nonNegativeInteger)
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- Succinimidyl 4-cyclohexane-1-carboxylate (en)
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- Succinimidyl 4-cyclohexane-1-carboxylate (en)
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| dbp:othernames
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- SMCC, 4-cyclohexanecarboxylic acid N-succinimidyl ester (en)
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| rdfs:comment
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- Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a heterobifunctional amine-to-sulfhydryl crosslinker, which contains two reactive groups at opposite ends: N-hydroxysuccinimide-ester and maleimide, reactive with amines and thiols respectively. SMCC is often used in bioconjugation to link proteins with other functional entities (fluorescent dyes, tracers, nanoparticles, cytotoxic agents). For example, a targeted anticancer agent – trastuzumab emtansine (antibody-drug conjugate containing an antibody trastuzumab chemically linked to a highly potent drug DM-1) – is prepared using SMCC reagent. (en)
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| rdfs:label
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- Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (en)
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- Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (en)
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