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The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.

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  • L'Élément régulateur 5' UTR Spi-1 (PU.1) est un élément ARN trouvé dans le 5' UTR de l'ARNm de Spi-1 qui est capable d'inhiber la traduction de transcripts Spi-1 par 8 fois. Spi-1 régule l'expression des gènes myéloïdes au cours du développement hématopoïétique. Des mutations dans cette région régulatrices du 5' UTR peuvent conduire à la surexpression de Spi-1 qui a été liée au développement de leucémies. (fr)
  • The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia. (en)
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dbp:caption
  • Predicted secondary structure and sequence conservation of Spi-1 (en)
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  • RF00232 (en)
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  • Spi-1 5′ UTR regulatory element (en)
dbp:rfam
  • RF00232 (en)
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dbp:symbol
  • Spi-1 (en)
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  • L'Élément régulateur 5' UTR Spi-1 (PU.1) est un élément ARN trouvé dans le 5' UTR de l'ARNm de Spi-1 qui est capable d'inhiber la traduction de transcripts Spi-1 par 8 fois. Spi-1 régule l'expression des gènes myéloïdes au cours du développement hématopoïétique. Des mutations dans cette région régulatrices du 5' UTR peuvent conduire à la surexpression de Spi-1 qui a été liée au développement de leucémies. (fr)
  • The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia. (en)
rdfs:label
  • Elément régulateur 5' UTR Spi-1 (PU.1) (fr)
  • Spi-1 (PU.1) 5′ UTR regulatory element (en)
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