About: Sitaxentan

Property	Value
dbo:abstract	Sitaxentan (Handelsname: Thelin®, Hersteller: , eine Tochterfirma des Pfizer-Konzerns) ist ein Endothelin-Rezeptorantagonist und war als Alternative zu Ambrisentan und Bosentan als so genanntes Orphan-Arzneimittel zur Behandlung des seltenen Lungenbluthochdrucks (Pulmonale Hypertonie, NYHA-Stadium III) zugelassen. (de) Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH). It was marketed as Thelin by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market due to concerns about liver toxicity. (en)
dbo:bioavailability	70.000000 (xsd:float)
dbo:casNumber	184036-34-8 210421-64-0 (sodium salt)
dbo:chEMBL	282724
dbo:drugbank	DB06268
dbo:fdaUniiCode	J9QH779MEM
dbo:kegg	D07171
dbo:pubchem	216235
dbo:thumbnail	wiki-commons:Special:FilePath/Sitaxentan.svg?width=300
dbo:wikiPageExternalLink	http://la-press.com/article.php%3Farticle_id=1420 https://archive.today/20030804040032/http:/www.chestjournal.org/cgi/content/abstract/121/6/1860 https://www.drugs.com/nda/thelin_050714.html http://www.americanheart.org/presenter.jhtml%3Fidentifier=4752
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dbo:wikiPageRevisionID	1073189152 (xsd:integer)
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dbp:atcPrefix	2.0
dbp:atcSuffix	KX03 (en)
dbp:bioavailability	70 (xsd:integer)
dbp:c	18 (xsd:integer)
dbp:casNumber	184036 (xsd:integer)
dbp:casSupplemental	210421 (xsd:integer)
dbp:chembl	282724 (xsd:integer)
dbp:chemspiderid	21106381 (xsd:integer)
dbp:cl	1 (xsd:integer)
dbp:drugbank	DB06268 (en)
dbp:eliminationHalfLife	36000.0
dbp:excretion	dbr:Kidney Fecal (en)
dbp:h	15 (xsd:integer)
dbp:innEma	sitaxentan sodium (en)
dbp:iupacName	N--2-4,5-(methylenedioxy)-o-tolyl]acetyl]-3-thiophenesulfonamide (en)
dbp:iupharLigand	3950 (xsd:integer)
dbp:kegg	D07171 (en)
dbp:legalStatus	Withdrawn (en)
dbp:licenceEu	yes (en)
dbp:metabolism	Hepatic (en)
dbp:n	2 (xsd:integer)
dbp:o	6 (xsd:integer)
dbp:proteinBound	>99% (en)
dbp:pubchem	216235 (xsd:integer)
dbp:routesOfAdministration	Oral (en)
dbp:s	2 (xsd:integer)
dbp:smiles	Cc1cc2OCOc2cc1CCc3sccc3SNc4oncc4Cl (en)
dbp:synonyms	TBC-11251 (en)
dbp:unii	J9QH779MEM (en)
dbp:width	225 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Reflist dbt:Fdacite dbt:Antihypertensives_and_diuretics dbt:Drugs.com dbt:PAH_rx
dcterms:subject	dbc:Endothelin_receptor_antagonists dbc:Benzodioxoles dbc:Chloroarenes dbc:Hepatotoxins dbc:Thiophenes dbc:Withdrawn_drugs dbc:Isoxazoles dbc:Sulfonamides
gold:hypernym	dbr:Medication
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAntihypertensiveAgents yago:WikicatMolecularFormulas yago:WikicatOrphanDrugs yago:WikicatSulfonamides yago:Abstraction100002137 yago:Agent109190918 yago:Agent114778436 yago:Antibacterial102716205 yago:CausalAgent100007347 yago:Communication100033020 yago:Drug103247620 yago:Formula106816935 yago:Matter100020827 yago:Medicine103740161 yago:Message106598915 yago:MolecularFormula106817173 yago:PhysicalEntity100001930 dbo:Drug yago:Statement106722453 yago:Substance100020090 yago:SulfaDrug104352070
rdfs:comment	Sitaxentan (Handelsname: Thelin®, Hersteller: , eine Tochterfirma des Pfizer-Konzerns) ist ein Endothelin-Rezeptorantagonist und war als Alternative zu Ambrisentan und Bosentan als so genanntes Orphan-Arzneimittel zur Behandlung des seltenen Lungenbluthochdrucks (Pulmonale Hypertonie, NYHA-Stadium III) zugelassen. (de) Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH). It was marketed as Thelin by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market due to concerns about liver toxicity. (en)
rdfs:label	Sitaxentan (de) Sitaxentan (en)
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prov:wasDerivedFrom	wikipedia-en:Sitaxentan?oldid=1073189152&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Sitaxentan.svg
foaf:isPrimaryTopicOf	wikipedia-en:Sitaxentan
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is foaf:primaryTopic of	wikipedia-en:Sitaxentan