About: Sibrafiban

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated.

Property	Value
dbo:abstract	Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated. (en)
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dbo:chEMBL	435176
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dbo:pubchem	5491394
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dbp:iupacName	[Z]--[&zwnj;[1-[2-[&zwnj;[4--benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxyl]-acetic ethyl ester (en)
dbp:kegg	D05834 (en)
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dcterms:subject	dbc:Abandoned_drugs dbc:Amidines dbc:Piperidines dbc:Prodrugs dbc:Benzamides dbc:Glycoprotein_IIb/IIIa_inhibitors dbc:Oximes
gold:hypernym	dbr:Prodrug
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rdfs:comment	Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated. (en)
rdfs:label	Sibrafiban (en)
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