About: Sequence feature variant type

The Sequence Feature Variant Type (SFVT) refers to the defined sequence variation (mutation) of a given sequence feature in a protein. Consider a protein, its amino acid sequence determines its structure and function. Some regions of the sequence are primarily related to the protein folding, thus the structure, while other regions are related to the protein function, such as an enzyme catalytic site. Across many related species, regions in a corresponding protein would remain conserved from species to species, while the exact amino acid at each location might, and often does, change. To clearly illustrate both the conserved nature of the functional regions and the precise change in the actual amino acid, the Sequence Feature Variant Type is defined.