dbo:abstract
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- Schizophyllan (Sonifilan, SPG) is a neutral extracellular polysaccharide produced by the fungus Schizophyllum commune. Schizophyllan is a β-1,3 beta-glucan with β-1,6 branching. Schizophyllan is also known as sizofiran. Schizophyllan has a molecular weight of 450,000 Da, and a specific rotation in water of +18-24°. A chemically analogous polysaccharide, scleroglucan, is formed by the fungus Athelia rolfsii. Both polysaccharides share the chemical structure of the backbone with curdlan. It is known for several things, including its ability to stimulate the immune system, carry metals in water, aid in delivering drugs, and use in some nanofibers. (en)
- シゾフィラン(sizofiran, schizophyllan)とは、抗悪性腫瘍剤の一種。スエヒロタケが産出する多糖類である。D-グルコースが主にβ1→3結合(β1,3-グルカン)、まれにβ1→6結合で連結した構造をしている。これによって、とても強固な三重螺旋構造を形成している。商品名はソニフィラン(SONIFILAN)。放射線療法と併用し、筋肉注射で用いる。 (ja)
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